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CAS RN: 100299-08-9 | Product Number: P2547
Pemirolast Potassium
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 9-Methyl-3-(1H-tetrazol-5-yl)-4H-pyrido[1,2-a]pyrimidin-4-one Potassium Salt
Product Documents:
| Size | Unit Price | Shanghai | Tianjin | Japan* |
|---|---|---|---|---|
| 1G |
¥190.00
|
1 | 1 | 8 |
| 5G |
¥830.00
|
Contact Us | Contact Us | 23 |
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| Product Number | P2547 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__0H__7KN__6O = 266.31 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Light Sensitive,Heat Sensitive |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 100299-08-9 |
| Related CAS RN | 69372-19-6 |
| Reaxys Registry Number | 8097604 |
| PubChem Substance ID | 354334415 |
| Merck Index (14) | 7078 |
| MDL Number | MFCD01690051 |
Specifications
| Appearance | Light yellow to Yellow to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
Properties (reference)
| Melting Point | 317 °C(dec.) |
| Solubility in water | Soluble |
| Solubility (insoluble in) | Ethanol |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. H361 : Suspected of damaging fertility or the unborn child. H362 : May cause harm to breast-fed children. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P263 : Avoid contact during pregnancy/ while nursing. P260 : Do not breathe dusts or mists. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P405 : Store locked up. |
Related Laws:
| RTECS# | UV1164470 |
Transport Information:
| Customs Control Conditions (Q) |
Application
Pemirolast Potassium: A Water-Soluble Inhibitor of Type I Allergy
Pemirolast potassium is a water-soluble inhibitor of type I allergy. Pharmacological studies indicate that it suppresses the formation of 1,2-diacylglycerol and phosphatidic acid, and the decrease in phosphatidylinositol (PI). It also can stabilize the cell membrane of mast cells, inhibit the inflow and release of Ca2＋, inhibit the activation of phosphodiesterase and increase the intracellular cAMP levels. Recently, some laboratory animal studies reported that it can reduce chemotherapy-induced nausea and vomiting. (The product is for research purpose only.)
References
- Effect of a Novel Antiallergic Drug, Pemirolast, on Activation of Rat Peritoneal Mast Cells: Inhibition of Exocytotic Response and Membrane Phospholipid Turnover
- Inhibitory effect of pemirolast, a novel antiallergic drug, on leukotriene C4 and granule protein release from human eosinophils
- Pemirolast reduces cisplatin-induced kaolin intake in rats
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