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CAS RN: 1263-89-4 | Product Number: P2092
Paromomycin Sulfate
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Purity: >92.0%(HPLC)
Synonyms:
Product Documents:
| Size | Unit Price | Shanghai | Tianjin | Japan* |
|---|---|---|---|---|
| 1G |
¥280.00
|
1 | 1 | 24 |
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| Product Number | P2092 |
| Purity / Analysis Method | >92.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__3H__4__5N__5O__1__4·xH__2SO__4 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 1263-89-4 |
| Related CAS RN | 7542-37-2&84420-34-8 |
| PubChem Substance ID | 253662559 |
| Merck Index (14) | 7041 |
| MDL Number | MFCD00079278 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 92.0 area% |
| Specific rotation [a]20/D | +47.0 to +55.0 deg(C=1, H2O) |
Properties (reference)
| Specific Rotation | 48° (C=1,H2O) |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
| RTECS# | WK2320000 |
Transport Information:
| Customs Control Conditions (Q) | Q类 （糖类，生物碱类，抗生素类，激素类） |
Application
Paromomycin: An Aminoglycoside Antibiotic against Bacteria, Protozoa and Cestodes
Paromomycin is an aminoglycoside antibiotic, first isolated from various Streptomyces in the 1950s. It is active against Gram-negative and many Gram-positive bacteria as well as some protozoa and cestodes. Paromomycin irreversibly binds to the 30S subunit (16S rRNA) of the bacterial ribosome as with any other aminoglycoside antibiotics, and then it inhibits bacterial growth by inhibiting protein synthesis. Paromomycin is mainly used for treatment of leishmaniasis and amoebic dysentery. (The product is for research purpose only.)
References
- Comparisons of ribosomal RNA sequences from amitochondrial protozoa: implications for processing, mRNA binding and paromomycin susceptibility
- The conformation of ribosomes and rRNA (a review)
- rRNA chemical groups required for aminoglycoside binding
- Paromomycin in the treatment of leishmaniasis
- Paromomycin (a review)
- A chemical assessment and HPLC assay validation of bulk paromomycin sulfate
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