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CAS RN: 28957-04-2 | Product Number: O0387
Oridonine
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Purity: >98.0%(HPLC)
Synonyms:
- (14R)-7α,20-Epoxy-1α,6β,7,14-tetrahydroxykaur-16-en-15-one
- (1α,6β,7α,14R)-7,20-Epoxy-1,6,7,14-tetrahydroxykaur-16-en-15-one
Product Documents:
| Size | Unit Price | Shanghai | Tianjin | Japan* |
|---|---|---|---|---|
| 50MG |
¥490.00
|
3 | Contact Us | 9 |
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| Product Number | O0387 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__0H__2__8O__6 = 364.44 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container | 50MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 28957-04-2 |
| Reaxys Registry Number | 1691227 |
| PubChem Substance ID | 468592517 |
| MDL Number | MFCD00221762 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Specific rotation | -57.0 to -61.0 deg (C=0.1, ethanol) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 252 °C |
| Maximum Absorption Wavelength | 237(EtOH) nm |
GHS
Related Laws:
| RTECS# | NZ8177000 |
Transport Information:
| Customs Control Conditions (Q) |
Application
Oridonin: An Active Diterpene with NLRP3 Inhibitory Activity
Oridonin (or oridonine) is an active diterpene isolated from Rabdosia rubescens used as a traditional Chinese medicine. Oridonin has been reported to possess a broad range of biological activities including anti-inflammation, anti-bacterial, anti-neoplastic and neuroprotective effects. It has recently been reported that NLR family pyrin domain-containing protein 3 (NLRP3), a pattern recognition receptor, forms a complex called NLRP3 inflammasome in response to irritating metabolites and pathogens, and induces the production of pro-inflammatory cytokines, Interleukin (IL)-1β and IL-18. Oridonin has also attracted attention as a NLRP3 inflammasome inhibitor which shows anti-inflammatory activity. (The product is for research purpose only.)
References
- Oridonin: An active diterpenoid targeting cell cycle arrest, apoptotic and autophagic pathways for cancer therapeutics (a review)
- Discovery and development of natural product oridonin-inspired anticancer agents (a review)
- Therapeutic potential of oridonin and its analogs: from anticancer and antiinflammation to neuroprotection
- Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity
- Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors (a review)
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