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CAS RN: 345627-80-7 | Product Number: N1274
SNS-032
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Purity: >95.0%(HPLC)(qNMR)
Synonyms:
- BMS 387032
- N-[5-[[[5-(tert-Butyl)oxazol-2-yl]methyl]thio]thiazol-2-yl]piperidine-4-carboxamide
- SNS 032
Product Documents:
| Size | Unit Price | Shanghai | Tianjin | Japan* |
|---|---|---|---|---|
| 10MG |
¥750.00
|
Contact Us | Contact Us | ≥40 |
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| Product Number | N1274 |
| Purity / Analysis Method | >95.0%(HPLC)(qNMR) |
| Molecular Formula / Molecular Weight | C__1__7H__2__4N__4O__2S__2 = 380.53 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (-20°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 345627-80-7 |
| Reaxys Registry Number | 9654646 |
| MDL Number | MFCD09833875 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(qNMR) | min. 95.0 % |
| Melting point | 170.0 to 174.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 172 °C |
GHS
Related Laws:
| RTECS# | TM6071000 |
Transport Information:
| Customs Control Conditions (Q) |
Application
SNS-032: A Cyclin-Dependent Kinase (CDK) Inhibitor
Cyclins and cyclin-dependent kinases (CDKs) are a key component of the regulatory proteins that control the cell cycle. CDK plays a critical role in regulating the cell cycle transition and is primarily involved in the pathogenesis of cancer. SNS-032 (BMS 387032) is a CDK inhibitor that competes for ATP binding sites on these kinases, thereby reducing tumor growth and inducing cell death. There are reports that SNS-032 inhibits CDK2, CDK7, and CDK9 and leads to growth arrest and apoptosis of tumor cell lines. (The product is for research purpose only.)
References
- N-(cycloalkylamino)acyl-2-aminothiazole inhibitors of cyclin-dependent kinase 2. N-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4- piperidinecarboxamide (BMS-387032), a highlyefficacious and selective antitumor agent
- Mechanism of action of SNS-032, a novel cyclin-dependent kinase inhibitor, in chronic lymphocytic leukemia
- SNS-032 is a potent and selective CDK 2, 7 and 9 inhibitor that drives target modulation in patient samples
- Discovery of BMS-387032, a potent cyclin-dependent kinase inhibitor in clinical development (a review)
- Cyclin-dependent kinase modulators and cancer therapy (a review)
Product Documents (Note: Some products will not have analytical charts available.)
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Specifications
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