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CAS RN: 527-73-1 | Product Number: N0891
2-Nitroimidazole
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Purity: >98.0%(T)(HPLC)
Synonyms:
- Azomycin
Product Documents:
| Size | Unit Price | Shanghai | Tianjin | Japan* |
|---|---|---|---|---|
| 1G |
¥310.00
|
4 | 1 | 8 |
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| Product Number | N0891 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__3H__3N__3O__2 = 113.08 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 527-73-1 |
| Reaxys Registry Number | 116444 |
| PubChem Substance ID | 160871493 |
| Merck Index (14) | 921 |
| MDL Number | MFCD00005185 |
Specifications
| Appearance | White to Yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
Properties (reference)
| Melting Point | 288 °C(dec.) |
| Solubility (soluble in) | Methanol, Acetone, Ethanol |
| Solubility (insoluble in) | Ether, Chloroform |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
Related Laws:
| RTECS# | NI7875000 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | III |
| Customs Control Conditions (Q) |
Application
抗菌活性を有するニトロイミダゾール系抗生物質，2-ニトロイミダゾール
2-Nitroimidazole (azomycin) is a nitroimidazole antibiotic such as metronidazole [M0924] and dimetridazole [D1564]. Azomycin was originally isolated from an unidentified soil bacterium Streptomyces sp. by Maeda et al. Azomycin can now be made by chemical synthesis. Azomycin is active against Gram-positive bacteria including mycobacteria, Gram-negative bacteria and protozoa. Azomycin have been reported as an inhibitor of bacterial ribonucleotide reductase. Meanwhile, several 2-nitroimidazoles have been reported as bioreductive markers for tumour hypoxia.
References
- A new antibiotic, azomycin
- K. Maeda, T. Osato, H. Umezawa, J. Antibiot. Ser. A 1953, 6, 182.
- Structure of azomycin, a new antibiotic
- Biological effects of azomycin (2-nitroimidazole). Inhibition of ribonucleotide reductase
- Basic Chemistry of 2-Nitroimidazoles (Azomycin Derivatives)
- Use of 2-nitroimidazoles as bioreductive markers for tumor hypoxia
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