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CAS RN: 55661-38-6 | Product Number: N0821
Nimustine Hydrochloride
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Purity: >98.0%(T)(HPLC)
Synonyms:
- ACNU
- 1-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-3-(2-chloroethyl)-3-nitrosourea Hydrochloride
Product Documents:
| Size | Unit Price | Shanghai | Tianjin | Japan* |
|---|---|---|---|---|
| 1G |
¥1,185.00
|
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| Product Number | N0821 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__9H__1__3ClN__6O__2·HCl = 309.15 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Condition to Avoid | Light Sensitive |
| CAS RN | 55661-38-6 |
| Related CAS RN | 42471-28-3&52208-23-8 |
| Reaxys Registry Number | 4220350 |
| PubChem Substance ID | 87560181 |
| Merck Index (14) | 6553 |
| MDL Number | MFCD01676942 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Argentometric Titration) | min. 98.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 186 °C |
| Solubility (soluble in) | Methanol |
| Solubility (insoluble in) | Benzene, Chloroform, Ether |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
Related Laws:
| RTECS# | YR8450000 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | III |
| Customs Control Conditions (Q) |
Application
水溶性のDNAアルキル化・架橋剤，塩酸ニムスチン
Nimustine (ACNU) hydrochloride (NSC 245382) is a water soluble DNA alkylating and crosslinking agent which induces DNA double-strand breaks (DSBs), but is not a simple alkylating agent. Thus, its exact mechanism of action has yet to be established. ACNU has been used for the treatment of gliomas. Recently, O6-methylguanine-DNA methyltransferase (MGMT) have received widespread attention. MGMT is a repair protein enzyme that specifically removes promutagenic alkyl groups from the O6 position of guanine in DNA. Repair of O6-alkylguanine adducts by tumour cells has been implicated in drug resistance since it reduces the cytotoxicity of alkylating agents including ACNU. (The product is for research purpose only.)
References
- 3-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-1-(2-chloroethyl)-1-nitrosourea hydrochloride. II. Effect of 3-[(4-amino-2-methyl-5-pyrimidinyl)ethyl]-1-(2-chloroethyl)-1-nitrosourea hydrochloride on lymphoid leukemia L-1210
- Studies on 3-[(4-amino-2-methyl-5-pyrimidinyl)-methyl]-1-(2-chloroethyl)-1-nitrosourea hydrochloride (NSC 245382). Part III. Antitumor activity of NSC 245382 in a variety of experimental tumors
- Potentiation by squalene of antitumor effect of 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-1-(2-chloroethyl)-1-nitrosourea in a murine tumor system
- O6-Methylguanine-DNA methyltransferase (MGMT) in normal tissues and tumors: Enzyme activity, promoter methylation and immunohistochemistry
- A Structural Insight into Major Groove Directed Binding of Nitrosourea Derivative Nimustine with DNA: A Spectroscopic Study
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