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CAS RN: 25137-00-2 | Product Number: N0654
(R)-(-)-3-Piperidinecarboxylic Acid
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Purity: >98.0%(T)
Synonyms:
- (R)-(-)-Nipecotic Acid
Product Documents:
| Size | Unit Price | Shanghai | Tianjin | Japan* |
|---|---|---|---|---|
| 1G |
¥155.00
|
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| 5G |
¥565.00
|
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| Product Number | N0654 |
| Purity / Analysis Method | >98.0%(T) |
| Molecular Formula / Molecular Weight | C__6H__1__1NO__2 = 129.16 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive |
| CAS RN | 25137-00-2 |
| Reaxys Registry Number | 81097 |
| PubChem Substance ID | 87573966 |
| MDL Number | MFCD01630787 |
Specifications
| Appearance | White powder to crystal |
| Purity(HPLC)(CAD) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Specific rotation [a]20/D | -5.0 to -6.0 deg(C=5, H2O) |
| Solubility in Water | almost transparency |
| NMR | confirm to structure |
Properties (reference)
| Specific Rotation | -5.5° (C=5,H2O) |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
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| Customs Control Conditions (Q) |
Application
GABA再取り込み阻害剤ニペコチン酸の活性エナンチオマー，(R)-(-)-ニペコチン酸
(R)-(-)-Nipecotic Acid is aγ-aminobutyric acid (GABA) reuptake inhibitor in vitro, used in scientific research. Some (R)-(-)-nipecotic acid prodrugs have been synthesized and evaluated for their bioactivity in vivo, such as the ethyl ester [N0655]. It is reported that (R)-(-)-nipecotic acid is the active enantiomer of nipecotic acid [N0420].
References
- Inhibition of the uptake of GABA and related amino acids in rat brain slices by the optical isomers of nipecotic acid
- Influence of inhibitors of the high affinity GABA uptake on seizure thresholds in mice
- Major human γ-aminobutyrate transporter: In silico prediction of substrate efficacy
- Assay for nipecotic acid in small blood samples by gas chromatography-mass spectroscopy
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