Metformin Hydrochloride

References

• Metformin regulates bone marrow stromal cells to accelerate bone healing in diabetic mice
  • Y. Guo, J. Wei, C. Liu, X. Li, W. Yan, eLife 2023, 12, e88310.
• The Differential Effect of Metformin on Osteocytes, Osteoblasts, and Osteoclasts
  • T.J. de Vries, A.S. Kleemann, J. Jin, T. Schoenmaker, Curr. Osteoporos. Rep. 2023, 21, 743.
• Metformin Enhances Osteogenesis and Suppresses Adipogenesis of Human Chorionic Villous Mesenchymal Stem Cells
  • Q. Gu, Y. Gu, H. Yang, Q. Shi, Tohoku J. Exp. Med. 2017, 241, 13.
• Metformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy status
  • X. Stephenne, M. Foretz, N. Taleux, G. C. van der Zon, E. Sokal, L. Hue, B. Viollet, B. Guigas, Diabetologia 2011, 54, 3101.
• Effect of Metformin on Bone Marrow Progenitor Cell Differentiation: In Vivo and In Vitro Studies
  • M.S. Molinuevo, L. Schurman, A.D. McCarthy, A.M. Cortizo, M.J. Tolosa, M.V. Gangoiti, V. Arnol, C. Sedlinsky, J. Bone Miner. Res. 2010, 25, 211.

Reference

• Repurposing metformin as a quorum sensing inhibitor in Pseudomonas aeruginosa
• H.A. Abbas, A.M. Elsherbini, M.A Shaldam, Afr. Health Sci. 2017, 17, 808.

References

• Metformin Restores Parkin-Mediated Mitophagy, Suppressed by Cytosolic p53
• Y.M. Song, W.K. Lee, Y.-H. Lee, E.S. Kang, B.-S. Cha, B.-W. Lee, Int. J. Mol. Sci. 2016, 17, 122

References

• Role of AMP-activated protein kinase in mechanism of metformin action
  • G. Zhou, R. Myers, Y. Li, Y. Chen, X. Shen, J. Fenyk-Melody, M. Wu, J. Ventre, T. Doebber, N. Fujii, N. Musi, M. F. Hirshman, L. J. Goodyear, D. E. Moller1, J. Clin. Invest. 2001, 108, 1167.
• Metformin Increases AMP-Activated Protein Kinase Activity in Skeletal Muscle of Subjects with Type 2 Diabetes
  • N. Musi, M. F. Hirshman, J. Nygren, M. Svanfeldt, P. Bavenholm, O. Rooyackers, G. Zhou, J. M. Williamson, O. Ljunqvist, S. Efendic, D. E. Moller, A. Thorell, L. J. Goodyear, Diabetes 2002, 51, 2074.
• The anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways
  • L. G. D. Fryer, A. Parbu-Patel, D. Carling, J. Biol. Chem. 2002, 277, 25226.
• The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism
  • S. A. Hawley, A. E. Gadalla, G. S. Olsen, D. G. Hardie, Diabetes 2002, 51, 2420.
• AMP-activated Protein Kinase is Required for the Lipid-lowering Effect of Metformin in Insulin-resistant Human HepG2 Cells
  • M. Zang, A. Zuccollo, X. Hou, D. Nagata, K. Walsh, H. Herscovitz, P. Brecher, N. B. Ruderman, R. A. Cohen, J. Biol. Chem. 2004, 279, 47898.
• The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin
  • R. J. Shaw, K. A. Lamia, D. Vasquez, S.-H. Koo, N. Bardeesy, R. A. DePinho, M. Montminy, L. C. Cantley, Science 2005, 310, 1642.
• Cellular and molecular mechanisms of metformin: an overview
  • B. Viollet, B. Guigas, N. S. Garcia, J. Leclerc, M. Foretz, F. Andreelli, Clin. Sci. 2012, 122, 253.
• The development and validation of liquid chromatography method for the simultaneous determination of metformin and glipizide, gliclazide, glibenclamide, or glimperide in plasma
  • S. AbuRuz, J. Millership, J. McElnay, J. Chromatogr. B 2005, 817, 277.

Reference

• M. D. Fullerton, S. Galic, K. Marcinko, S. Sikkema, T. Pulinilkunnil, Z.-P. Chen, H. M. O'Neill, R. J. Ford, R. Palanivel, M. O'Brien, D. G. Hardie, S. L. Macaulay, J. D. Schertzer, J. R. B. Dyck, B. J. van Denderen, B. E. Kemp, G. R. Steinberg, Nat. Med. 2013, 19,1649.