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CAS RN: 136790-76-6 | Product Number: L0355
Lubiprostone
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Purity: >97.0%(HPLC)
Synonyms:
- 16,16-Difluoro-11α-hydroxy-9,15-dioxoprostan-1-oic Acid
- 7-[(1R,2R,3R)-2-(4,4-Difluoro-3-oxooctyl)-3-hydroxy-5-oxocyclopentyl]heptanoic Acid
Product Documents:
| Size | Unit Price | Shanghai | Tianjin | Japan* |
|---|---|---|---|---|
| 50MG |
¥1,210.00
|
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| Product Number | L0355 |
| Purity / Analysis Method | >97.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__0H__3__2F__2O__5 = 390.47 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 136790-76-6 |
| Reaxys Registry Number | 15639299 |
| PubChem Substance ID | 468592162 |
| MDL Number | MFCD20268389 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC)(CAD) | min. 97.0 area% |
| Purity(Neutralization titration) | min. 97.0 % |
| Melting point | 58.0 to 62.0 °C |
| Specific rotation | -52.0 to -56.0 deg(C=1, THF) |
Properties (reference)
| Melting Point | 60 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
| RTECS# | UK8257750 |
Transport Information:
| Customs Control Conditions (Q) |
Application
Lubiprostone: A Locally Acting Type II Chloride Channel (CIC-2) Activator in the Small Intestinal Epithelial Cells
Lubiprostone (SPI-0211) is a fatty acid metabolite analog of prostaglandin E1. It has been reported that lubiprostone is a locally acting type II chloride channel (ClC-2) activator in the small intestinal epithelial cells, and enhances a chloride-rich intestinal fluid secretion without altering sodium and potassium concentrations in the serum. By increasing intestinal fluid secretion, lubiprostone increases motility in the intestine, thereby facilitating the passage of stool and alleviating symptoms associated with chronic idiopathic constipation. (The product is for research purpose only.)
References
- SPI-0211 activates T84 cell chloride transport and recombinant human ClC-2 chloride currents
- Lubiprostone: A Chloride Channel Activator (a review)
Product Documents (Note: Some products will not have analytical charts available.)
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