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CAS RN: 137-58-6 | Product Number: L0156
Lidocaine
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Purity: >99.0%(T)(HPLC)
Synonyms:
- 2-Diethylamino-N-(2,6-dimethylphenyl)acetamide
Product Documents:
| Size | Unit Price | Shanghai | Tianjin | Japan* |
|---|---|---|---|---|
| 25G |
¥80.00
|
14 | 5 | ≥100 |
| 100G |
¥280.00
|
3 | 1 | ≥40 |
| 500G |
¥970.00
|
1 | 4 | ≥80 |
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| Product Number | L0156 |
| Purity / Analysis Method | >99.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__4H__2__2N__2O = 234.34 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive |
| CAS RN | 137-58-6 |
| Reaxys Registry Number | 2215784 |
| PubChem Substance ID | 87572107 |
| SDBS (AIST Spectral DB) | 27423 |
| Merck Index (14) | 5482 |
| MDL Number | MFCD00026733 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 99.0 area% |
| Purity(Nonaqueous Titration) | min. 99.0 % |
| Melting point | 66.0 to 70.0 °C |
| Solubility in Methanol | almost transparency |
Properties (reference)
| Melting Point | 69 °C |
| Boiling Point | 182 °C/4 mmHg |
| Solubility in water | Insoluble |
| Degree of solubility in water | 410 mg/l 30 °C |
| Solubility (soluble in) | Alcohol, Benzene, Ether, Chloroform |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H302 : Harmful if swallowed. H362 : May cause harm to breast-fed children. H370 : Causes damage to organs. H372 : Causes damage to organs through prolonged or repeated exposure. H317 : May cause an allergic skin reaction. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P263 : Avoid contact during pregnancy/ while nursing. P272 : Contaminated work clothing should not be allowed out of the workplace. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves. P302 + P352 : IF ON SKIN: Wash with plenty of water. P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor. P362 + P364 : Take off contaminated clothing and wash it before reuse. P333 + P313 : If skin irritation or rash occurs: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P405 : Store locked up. |
Related Laws:
| RTECS# | AN7525000 |
Transport Information:
| Customs Control Conditions (Q) |
Application
Lidocaine: A Voltage Gated Sodium Channel Blocker
Lidocaine is widely used for regional anesthesia and postoperative pain relief, and these effects involve the blockade of voltage-dependent sodium channels which play a key role in the pathogenesis of neuropathic pain. Thus, lidocaine stabilizes the neuronal cell membrane by inhibiting the movement of sodium ions into a nerve cell. Lignocaine is also a class IB antiarrhythmic agent as a sodium channel blocker. Lidocaine is metabolized rapidly by CYP1A2 and CYP3A4 in liver to main active metabolites, monoethylglycine xylidide (MEGX) [N1171] and glycinexylidide (GX) [G0579]. (The product is for research purpose only.)
References
- Lidocaine block of cardiac sodium channels
- Molecular determinants of state-dependent block of Na+ channels by local anesthetics
- The role of sodium channels in chronic inflammatory and neuropathic pain (a review)
- High-performance liquid chromatography-tandem electrospray mass spectrometry for the determination of lidocaine and its metabolites in human plasma and urine
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