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CAS RN: 78755-81-4 | Product Number: F0958
Flumazenil
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Purity: >99.0%(GC)
Synonyms:
- Ro 15-1788
Product Documents:
| Size | Unit Price | Shanghai | Tianjin | Japan* |
|---|---|---|---|---|
| 25MG |
¥200.00
|
2 | 1 | 13 |
| 100MG |
¥390.00
|
1 | 1 | 6 |
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| Product Number | F0958 |
| Purity / Analysis Method | >99.0%(GC) |
| Molecular Formula / Molecular Weight | C__1__5H__1__4FN__3O__3 = 303.29 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container | 100MG-Glass Bottle with Plastic Insert (View image), 25MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 78755-81-4 |
| Reaxys Registry Number | 4763661 |
| PubChem Substance ID | 253662580 |
| Merck Index (14) | 4135 |
| MDL Number | MFCD00242764 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(GC) | min. 99.0 % |
| Melting point | 198.0 to 202.0 °C |
Properties (reference)
| Melting Point | 200 °C |
GHS
| Signal Word | Warning |
| Hazard Statements | H303 : May be harmful if swallowed. |
| Precautionary Statements | P312 : Call a POISON CENTER/doctor if you feel unwell. |
Related Laws:
| RTECS# | N12922170 |
Transport Information:
| Customs Control Conditions (Q) |
Application
Flumazenil: a potent benzodiazepine receptor antagonist
Flumazenil (code name Ro 15-1788) was first developed as an anti-anxiety agent in 1979. In subsequent studies have been demonstrated that flumazenil acts as a potent benzodiazepine receptor antagonist and a partial benzodiazepine receptor agonist. Flumazenil inhibits the central effects of benzodiazepine agonists by competing with these drugs for the benzodiazepine receptor. Then, flumazenil is used for the treatment of benzodiazepine overdoses. (The product is for research purpose only.)
References
- Selective antagonists of benzodiazepines
- Intrinsic actions of the benzodiazepine receptor antagonist Ro 15-1788 (a review)
- Flumazenil: a reappraisal of its pharmacological properties and therapeutic efficacy as a benzodiazepine antagonist (a review)
- SB242084, flumazenil, and CRA1000 block ethanol withdrawal-induced anxiety in rats
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