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CAS RN: 26016-99-9 | Product Number: F0889
Fosfomycin Disodium Salt
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Purity: >98.0%(T)(HPLC)
Synonyms:
- Phosphomycin Disodium Salt
- Disodium (1R,2S)-1,2-Epoxypropylphosphonate
- (1R,2S)-1,2-Epoxypropylphosphonic Acid Disodium Salt
Product Documents:
| Size | Unit Price | Shanghai | Tianjin | Japan* |
|---|---|---|---|---|
| 5G |
¥130.00
|
Contact Us | Contact Us | ≥80 |
| 25G |
¥310.00
|
Contact Us | Contact Us | 1 |
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| Product Number | F0889 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__3H__5Na__2O__4P = 182.02 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 26016-99-9 |
| Related CAS RN | 23155-02-4 |
| Reaxys Registry Number | 4604425 |
| PubChem Substance ID | 253660394 |
| MDL Number | MFCD00056853 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC)(CAD) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Specific rotation [a]20/D | -3.5 to -5.5 deg(C=5, H2O) |
Properties (reference)
| Specific Rotation | -5° (C=5,H2O) |
| Solubility (slightly sol. in) | Methanol |
GHS
| Signal Word | Warning |
| Hazard Statements | H303 : May be harmful if swallowed. |
| Precautionary Statements | P312 : Call a POISON CENTER/doctor if you feel unwell. |
Related Laws:
| RTECS# | SZ7902000 |
Transport Information:
| Customs Control Conditions (Q) | Q类 （糖类，生物碱类，抗生素类，激素类） |
Application
Fosfomycin: A Broad-Spectrum Antibiotic with Inactivating UDP-N-Acetylglucosamine-3-enolpyruvyl Transferase (MurA)
Fosfomycin (also known as phosphomycin), a broad-spectrum antibiotic, was isolated from Streptomyces fradiase in 1969. It can now be made by chemical synthesis. Fosfomycin has bactericidal activity against a wide range of bacteria, including Gram-negative micro-organisms and some Gram-positive bacteria, such as staphylococci. Fosfomycin interferes with cell wall synthesis in bacteria by inhibiting the initial step by inactivating UDP-N-acetylglucosamine-3-enolpyruvyl transferase, also known as MurA.
References
- Mechanism of action of fosfomycin (phosphonomycin)
- Structure of UDP-N-acetylglucosamine enolpyruvyl transferase, and enzyme essential for the synthesis of bacterial peptidoglycan, complexed with substrate UDP-N-acetylglucosamine and the drug fosfomycin
- Kinetics, Stoichiometry, and Identification of the Reactive Thiolate in the Inactivation of UDP-GlcNAc Enolpyruvoyl Transferase by the Antibiotic Fosfomycin
- Characterization of a Cys115 to Asp substitution in the Escherichia coli cell wall biosynthetic enzyme UDP-GlcNAc Enolpyruvyl Transferase (MurA) that confers resistance to inactivation by the antibiotic fosfomycin
- Fosfomycin for the treatment of multidrug-resistant, including extended-spectrum β-lactamase producing, Enterobacteriaceae infections: a systematic review
- Fosfomycin: evaluation of the published evidence on the emergence of antimicrobial resistance in Gram-negative pathogens (a review)
PubMed Literature
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