Maximum quantity allowed is 999
Please select the quantity
CAS RN: 571203-78-6 | Product Number: E1524
Erastin
×
![]()
×
Purity: >98.0%(HPLC)(qNMR)
Synonyms:
- 2-[1-[4-[2-(4-Chlorophenoxy)acetyl]piperazin-1-yl]ethyl]-3-(2-ethoxyphenyl)quinazolin-4(3H)-one
Product Documents:
| Size | Unit Price | Shanghai | Tianjin | Japan* |
|---|---|---|---|---|
| 5MG |
¥430.00
|
Contact Us | Contact Us | 5 |
* For order or inquiry, please contact
Our Authorized Distributors.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
* To send your quote request for bulk quantities, please click on the "Request Bulk Quote" button. Please note that we cannot offer bulk quantities for some products.
| Product Number | E1524 |
| Purity / Analysis Method | >98.0%(HPLC)(qNMR) |
| Molecular Formula / Molecular Weight | C__3__0H__3__1ClN__4O__4 = 547.05 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (-20°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 571203-78-6 |
| Reaxys Registry Number | 14580272 |
| MDL Number | MFCD09837984 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(qNMR) | min. 98.0 % |
| NMR | confirm to structure |
Properties (reference)
GHS
Related Laws:
Transport Information:
| Customs Control Conditions (Q) |
Application
Erastin: Inducer of Ferroptosis
References
- 1) Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
- 2) Ablation of the Ferroptosis Inhibitor Glutathione Peroxidase 4 in Neurons Results in Rapid Motor Neuron Degeneration and Paralysis
- 3) Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice
Application
Erastin: A Ferroptosis Inducer
Erastin is a ferroptosis inducer. Ferroptosis is a type of programmed cell death dependent on iron and characterized by the accumulation of lipid reactive oxygen species. There are reports that erastin inhibits cystine uptake by the cystine/glutamate antiporter (system xc-), which helps maintain the redox state. This inhibition creates a void in the cell's antioxidant defenses and ultimately leads to iron-dependent oxidative death (ferroptosis). In addition, activation of ferroptosis results in the non-apoptotic destruction of certain cancer cells. (The product is for research purpose only.)
References
- Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
- Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis
- Ferroptosis: a novel anti-tumor action for cisplatin
- Broadening horizons: the role of ferroptosis in cancer (a review)
Articles/Brochures
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
Please select Language.
The requested SDS is not available.
Please Contact Us for more information.
Specifications
C of A & Other Certificates
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
Sample C of A
This is a sample C of A and may not represent a recently manufactured lot of the product.
A sample C of A for this product is not available at this time.
Analytical Charts
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
The requested analytical chart is not available. Sorry for the inconvenience.