Maximum quantity allowed is 999
CAS RN: 93183-36-9 | Product Number: D6204
Diisopropylammonium Tetrazol-1-ide
Purity: >98.0%(T)(HPLC)
- Diisopropylammonium Tetrazolide
| Size | Unit Price | Shanghai | Tianjin | Japan* |
|---|---|---|---|---|
| 5G |
¥750.00
|
Contact Us | Contact Us | 32 |
| 25G |
¥1,390.00
|
1 | Contact Us | 8 |
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| Product Number | D6204 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__6H__1__5N·CH__2N__4 = 171.25 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Hygroscopic,Heat Sensitive |
| CAS RN | 93183-36-9 |
| Reaxys Registry Number | 3569216 |
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 150.0 to 154.0 °C |
| NMR | confirm to structure |
| Melting Point | 152 °C |
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
| Customs Control Conditions (Q) |
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Used Chemicals
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Procedure
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2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite (0.7 mL, 2.2 mmol, 1.2 eq.) was added to a solution of DMT-T (1.0 g, 1.8 mmol) and diisopropylammonium tetrazole (160 mg, 0.92 mmol, 0.5 eq.) in dichloromethane (9.2 mL) at room temperature. After the completion of the reaction, saturated aq. NaHCO3 (5 mL) was added to the solution and extracted with dichloromethane (15 mL, twice). The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (hexane:ethyl acetate = 70:30 - 50:50, 2% of triethylamine was added to the eluents) to give 1 (1.2 g, 88% yield) as a white crystal.
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Experimenter’s Comments
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The reaction solution was monitored by NMR.
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Analytical Data
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Compound 1
1H NMR (400 MHz, CDCl3); δ 11.36 (s, 1H), 7.50 (d, J = 4.0 Hz, 1H), 7.36-7.20 (m, 9H), 6.87-6.83 (m, 4H), 6.16-6.15 (m, 1H), 4.56-4.49 (m, 1H), 3.99 (d, J = 4.0 Hz, 1H), 3.73-3.72 (m, 1H), 3.22-3.19 (m, 1H), 2.72 (t, J = 8.0 Hz, 1H), 2.62 (t, J = 1.2 Hz, 1H), 2.41-2.31 (m, 1H), 1.44 (d, J = 1.2 Hz, 3H), 1.18-1.06 (m, 12H).
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Lead Reference
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- Lewis acid deprotection of silyl-protected oligonucleotides and base-sensitive oligonucleotide analogs
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Other Reference
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- Microwave-assisted preparation of nucleoside-phosphoramidites
Safety Data Sheet (SDS)
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Specifications
C of A & Other Certificates
Sample C of A
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Analytical Charts
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