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CAS RN: 85031-59-0 | Product Number: D6147
Dihydroartemisinic acid
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Purity: >98.0%(GC)(T)
Synonyms:
- (R)-2-[(1R,4R,4aS,8aS)-4,7-Dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalen-1-yl]propanoic Acid
- (αR,1R,4R,4aS,8aS)-1,2,3,4,4a,5,6,8a-Octahydro-α,4,7-trimethyl-1-naphthaleneacetic Acid
Product Documents:
| Size | Unit Price | Shanghai | Tianjin | Japan* |
|---|---|---|---|---|
| 200MG |
¥310.00
|
3 | Contact Us | 1 |
| 1G |
¥1,040.00
|
3 | Contact Us | 17 |
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| Product Number | D6147 |
| Purity / Analysis Method | >98.0%(GC)(T) |
| Molecular Formula / Molecular Weight | C__1__5H__2__4O__2 = 236.36 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image), 200MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 85031-59-0 |
| Reaxys Registry Number | 3546237 |
| MDL Number | MFCD16876168 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(GC) | min. 98.0 % |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 137.0 to 141.0 °C |
| Specific rotation | -15.0 to -19.0 deg(C=1, CHCl3) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 140 °C |
GHS
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Application
Dihydroartemisinic Acid: A Biosynthetic Precursor and Synthetic Intermediate of the Antimalarial Agent Artemisinin
Dihydroartemisinic acid is a biosynthetic precursor of the antimalarial agent artemisinin [A2118]. It undergoes a spontaneous endoperoxide-forming cascade reaction to yield artemisinin in the presence of air.1,2) Dihydroartemisinic acid is also a synthetic intermediate of artemisinin from artemisinic acid.3)
References
- 1) Synthesis of [3,3-2H2]-Dihydroartemisinic Acid to Measure the Rate of Nonenzymatic Conversion of Dihydroartemisinic Acid to Artemisinin
- 2) Synthesis of [15,15,15-2H3]-Dihydroartemisinic Acid and Isotope Studies Support a Mixed Mechanism in the Endoperoxide Formation to Artemisinin
- 3) Semisynthetic Artemisinin, the Chemical Path to Industrial Production
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