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CAS RN: 6559-91-7 | Product Number: D5653
4'-Demethylepipodophyllotoxin
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Purity: >98.0%(HPLC)
Synonyms:
- (5R,5aR,8aR,9S)-9-Hydroxy-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,5a,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(8H)-one
Product Documents:
| Size | Unit Price | Shanghai | Tianjin | Japan* |
|---|---|---|---|---|
| 1G |
¥130.00
|
1 | Contact Us | 3 |
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| Product Number | D5653 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__1H__2__0O__8 = 400.38 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (-20°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 6559-91-7 |
| Reaxys Registry Number | 1358259 |
| PubChem Substance ID | 468591478 |
| MDL Number | MFCD00189421 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Specific rotation [a]20/D | -68.0 to -60.0 deg(C=0.65, MeOH) |
Properties (reference)
| Melting Point | 255 °C |
| Specific Rotation | -64° (C=0.65,MeOH) |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H360 : May damage fertility or the unborn child. H350 : May cause cancer. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
Related Laws:
| RTECS# | LV2476200 |
Transport Information:
| Customs Control Conditions (Q) |
Application
4'-Demethylepipodophyllotoxin: A Key Synthetic Intermediate for the Preparation of Podophyllotoxin-Type Anti-Tumor Agents
4'-Demethylepipodophyllotoxin is a key synthetic intermediate for the preparation of podophyllotoxin[P1771]-type anti-tumor agents, including etoposide [E0675]. 4'-Demethylepipodophyllotoxin is also an antimitotic agent which binds to monomeric tubulin, preventing micro-tubule polymerization. (The product is for research purpose only.)
References
- Antitumor agents. 113. New 4β-arylamino derivatives of 4'-O-demethylepipodophyllotoxin and related compounds as potent inhibitors of human DNA topoisomerase II
- Antitumor agents. 120. New 4-substituted benzylamine and benzyl ether derivatives of 4'-O-demethylepipodophyllotoxin as potent inhibitors of human DNA topoisomerase II
- Antitumor agents. 124. New 4β-substituted aniline derivatives of 6,7-O,O-demethylene-4'-O-demethylpodophyllotoxin and related compounds as potent inhibitors of human DNA topoisomerase II
- Synthesis and biological study of a new series of 4'-demethylepipodophyllotoxin derivatives
- Structure of 4’-demethylepipodophyllotoxin in complex with tubulin provides a rationale for drug design
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