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CAS RN: 1091-85-6 | Product Number: D5406
Dansylglycine [for Albumin binding assay]
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![Dansylglycine [for Albumin binding assay]](/_ui/responsive/theme-tci/images/missing_product_zoom.jpg "Dansylglycine [for Albumin binding assay]")
Purity: >98.0%(T)
Synonyms:
- N-[5-(Dimethylamino)naphthalene-1-sulfonyl]glycine
- Dns-Gly-OH
Product Documents:
| Size | Unit Price | Shanghai | Tianjin | Japan* |
|---|---|---|---|---|
| 25MG |
¥120.00
|
1 | Contact Us | 34 |
| 100MG |
¥320.00
|
Contact Us | Contact Us | 25 |
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| Product Number | D5406 |
| Purity / Analysis Method | >98.0%(T) |
| Molecular Formula / Molecular Weight | C__1__4H__1__6N__2O__4S = 308.35 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Condition to Avoid | Light Sensitive |
| CAS RN | 1091-85-6 |
| Reaxys Registry Number | 2223701 |
| PubChem Substance ID | 354335222 |
| SDBS (AIST Spectral DB) | 11221 |
| MDL Number | MFCD00037734 |
Specifications
| Appearance | Light yellow to Yellow to Green powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 156.0 to 161.0 °C |
| Human serum albmin (HSA) binding activity | S/N ratio min. 8 |
| Competitive avtivity in competitive drug | Remaining fluorescein inensity max. 30 % |
| Non-competitive avtivity in non-competitive drug | Remaining fluoresein intensity min. 80 % |
Properties (reference)
| Melting Point | 159 °C |
GHS
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Application
Fluorescent Probes for the Characterization of Two Specific Drug Binding Sites on HSA
Human Serum Albumin (HSA) binds to a wide variety of drugs at two primary binding sites (I: blue and II: yellow), and can have a significant impact on their pharmacokinetics and pharmacological effects. The fluorescent probes, dansylamide (1) and dansylglycine (2) selectively interact with sites I and II, respectively.1,2) BD140 (3) also binds to drug binding site II specifically.3) Changes in probe fluorescence are analyzed by fluorescence titrations as a result of competitive displacement by drugs and pharmaceuticals. The pattern of fluorescent probe displacement by these reagents enabled the identification of two specific drug binding sites, which illustrates their usefulness for the characterization of the binding sites in HSA.
References
- 1)The Characterization of Two Specific Drug Binding Sites on Human Serum Albumin
- 2)Further Characterization of Specific Drug Binding Sites on Human Serum Albumin
- 3)Fluorescent Dye Cocktail for Multiplex Drug-Site Mapping on Human Serum Albumin
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Specifications
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Other Documents
Related Products
Dansylglycine
| Product # | D1501 |
| CAS RN | 1091-85-6 |
| Purity / Analysis Method: | >98.0%(T) |