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CAS RN: 106092-09-5 | Product Number: D4337
(S)-(-)-2,6-Diamino-4,5,6,7-tetrahydrobenzothiazole
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Purity: >98.0%(GC)(T)
Synonyms:
- (S)-N-Despropyl Pramipexole
Product Documents:
| Size | Unit Price | Shanghai | Tianjin | Japan* |
|---|---|---|---|---|
| 1G |
¥95.00
|
3 | 1 | 5 |
| 5G |
¥440.00
|
1 | Contact Us | 11 |
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| Product Number | D4337 |
| Purity / Analysis Method | >98.0%(GC)(T) |
| Molecular Formula / Molecular Weight | C__7H__1__1N__3S = 169.25 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Light Sensitive,Moisture Sensitive,Heat Sensitive |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 106092-09-5 |
| Reaxys Registry Number | 6477896 |
| PubChem Substance ID | 253659814 |
| MDL Number | MFCD07368003 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(GC) | min. 98.0 % |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 227.0 to 231.0 °C |
| Specific rotation [a]20/D | -94.0 to -98.0 deg(C=1,MeOH) |
Properties (reference)
| Melting Point | 229 °C |
| Specific Rotation | -96° (C=1,MeOH) |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
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Application
A Key Synthetic Building Block of Pramipexole (Dopamine D3 Receptor Agonist) and Antileukemic Agents
This compound is a key synthetic building block of pramipexole [P2073] which is a dopamine D3 receptor agonist.1-4) From 2010, this compound also used as a synthetic building block of thiazole derivatives as antileukemic agents.5-7)
References
- 1)Dopamine autoreceptor agonists: resolution and pharmacological activity of 2,6-diaminotetrahydrobenzothiazole and an aminothiazole analog of apomorphine
- 2)Design, Synthesis, and Evaluation of Potent and Selective Ligands for the Dopamine 3 (D3) Receptor with a Novel in Vivo Behavioral Profile
- 3)A Novel Scalable Synthesis of Pramipexole
- 4)Development of a Validated LC Method for Separation of Process-Related Impurities Including the R-enantiomer of S-Pramipexole on Polysaccharide Chiral Stationary Phases
- 5)Synthesis and Identification of a new class of antileukemic agents containing 2-(arylcarboxamide)-(S)-6-amino- 4,5,6,7-tetrahydrobenzo[d]thiazole
- 6)Synthesis and antileukemic activity of 1-((S)-2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)-3-(substitutedphenyl)urea derivatives
- 7)Synthesis and identification of a new class of (S)-2,6-diamino-4,5,6,7-tetrahydrobenzo[d]thiazole derivatives as potent antileukemic agents
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