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CAS RN: 69123-98-4 | Product Number: D4200

Fialuridine

Purity: >98.0%(HPLC)

Synonyms:

1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodouracil
FIAU
2'-Fluoro-5-iodoarauracil

Product Documents:

Size	Unit Price	Shanghai	Tianjin	Japan*
10MG	¥805.00	Contact Us	Contact Us	1

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Supplemental Product Information:

This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.

General Information plus

Product Number	D4200
Purity / Analysis Method	>98.0%(HPLC)
Molecular Formula / Molecular Weight	C__9H__1__0FIN__2O__5 = 372.09
Physical State (20 deg.C)	Solid
Storage Temperature	Refrigerated (0-10°C)
Condition to Avoid	Heat Sensitive
CAS RN	69123-98-4
Reaxys Registry Number	892318
PubChem Substance ID	160871154
Merck Index (14)	4069
MDL Number	MFCD00866922

Specifications & Documents plus

Specifications

Appearance	White to Almost white powder to crystal
Purity(HPLC)	min. 98.0 area%

Properties (reference)

Melting Point

226 °C

Safety & Properties plus

GHS

Related Laws:

RTECS#

YQ9512500

Transport Information:

Customs Control Conditions (Q)

Applications & Literature plus

Application

Fialuridine (FIAU): A Thymidine Nucleoside Analog with Activity against Herpes Viruses and Hepatitis B Virus (HBV)

Fialuridine (FIAU) is a thymidine nucleoside analog with activity against various herpes viruses and hepatitis B virus (HBV). FIAU blocks the action of DNA polymerases, thus inhibiting viral replication. FIAU owes its effect to preferential phosphorylation by virus-encoded thymidine kinase to its 5'-diphosphate form. After further conversion to triphosphate form, it acts as an inhibitor or alternate substrate for the viral DNA polymerase. On the other hand, it appear that FIAU causes mitochondrial toxicity leading to fatal liver failure alongside lactic acidosis. (The product is for research purpose only.)