Product Number	D3371
Molecular Formula / Molecular Weight	H₆Cl₂N₂Pt = 300.05
Physical State (20 deg.C)	Solid
Storage Temperature	Room Temperature (Recommended in a cool and dark place, <15°C)
Store Under Inert Gas	Store under inert gas
Condition to Avoid	Moisture Sensitive
Packaging and Container	100MG-Glass Bottle with Plastic Insert (View image)
CAS RN	15663-27-1
PubChem Substance ID	87558796
Merck Index (14)	2317

Specifications

Appearance	Light orange to Yellow to Green powder to crystal
Elemental analysis(Nitrogen)	8.90 to 9.80 %

Properties (reference)

Melting Point	270 °C
Degree of solubility in water	2,530 mg/l 25 °C
Solubility (soluble in)	Dimethylformamide

GHS

Pictogram
Signal Word	Danger
Hazard Statements	H300 : Fatal if swallowed. H316 : Causes mild skin irritation. H319 : Causes serious eye irritation. H360 : May damage fertility or the unborn child. H362 : May cause harm to breast-fed children. H370 : Causes damage to organs. H372 : Causes damage to organs through prolonged or repeated exposure. H340 : May cause genetic defects. H350 : May cause cancer.
Precautionary Statements	P501 : Dispose of contents/ container to an approved waste disposal plant. P263 : Avoid contact during pregnancy/ while nursing. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up.

Related Laws:

RTECS#

TP2450000

Transport Information:

UN Number	UN3288
Class	6.1
Packing Group	II
Customs Control Conditions (Q)

Application

Quorum sensing inhibitor

Reference

The Role of Drug Repurposing in the Development of Novel Antimicrobial Drugs: Non-Antibiotic Pharmacological Agents as Quorum Sensing-Inhibitors

M. Gajdács, G. Spengler, Antibiotics 2019, 8, 270.

Application

Platinum Coordination Complexes as Antitumor Agents

D3371

The development of platinum coordination complexes as antitumor agents began in the 1960s, and the highest antitumor activity was exhibited by cisplatin, approved by FDA in 1978. Improved versions carboplatin [C2043] and oxaliplatin [O0372] were developed to avoid the serious side effects and the problem with resistance associated with the use of cisplatin.^1-5)
The platinum complexes diffuse to the tumor cell, where they undergo hydrolysis displacement of their one chloride or carboxylate group leading to a platinum cation. The resulting cation coordinates to the guanine N⁷-position of DNA give a coordination cation. Then, intrastrand cross-linking occurs to anther guanine via further hydrolysis displacement of the remaining chloride or carboxylate. The forming [Pt(NH₂R)₂]²⁺ ― DNA complex distort the DNA helix (Fig. 1 and 2)⁶⁾. Thus, DNA duplication is hindered, which ultimately triggers tumor cell apoptosis.³⁾

References

Application

Reagent for renal failure model

References

Cis-diamminedichloroplatinum (DDP) induced acute renal failure (ARF): attempts at amelioration
- S. Chopra, J. Kaufman, W. Flamenbaum, Clin. Exp. Dial. Apheresis. 1983, 7, 25.
Cis-diamminedichloroplatinum (II)-induced acute renal failure in the rat: enzyme histochemical studies
- T. W. Jones, S. Chorpa, J. S. Kaufman, W. Flamenbaum, B.F. Trump, Toxicol. Pathol. 1985, 13, 296.
Cis-diamminedichloroplatinum (II)-induced acute renal failure in the rat. Correlation of structural and functional alterations
- T. W. Jones, S. Chopra, J. S. Kaufman, W. Flamenbaum, B. F. Trump, Lab. Invest. 1985, 52, 363.
Protective effects of dithiocarbamates against renal toxicity of cis-diamminedichloroplatinum in rats
- S. Hidaka, M. Tsuruoka, T. Funakoshi, H. Shimada, M. Kiyozumi, S. Kojima, Ren. Fail. 1994, 16, 337.
Celecoxib, a selective cyclooxygenase-2 inhibitor, attenuates renal injury in a rat model of Cisplatin-induced nephrotoxicity
- G. M. Suddek, A. E. El-Kenawi, A. Abdel-Aziz, H. A. El-Kashef, Chemotherapy 2011, 57, 321.
Effect of fructose-1,6-bisphosphate on the nephrotoxicity induced by cisplatin in rats
- A. A. Azambuja, A. Lunardelli, F. B. Nunes, P. B. Gaspareto, M. V. Donadio, C. E. de Figueiredo , J. R. de Oliveira, Inflammation 2011, 34, 67.
Reduction of oxidative stress may play a role in the anti-inflammatory effect of the novel herbal formulation in a rat model of hydrochloric acid-induced cystitis
- W. J. Bae, U. S. Ha, S. Kim, S. J. Kim, S. H. Hong, J. Y. Lee, T. K. Hwang, S. Y. Hwang, H. J. Kim, S. W. Kim, Neurourol. Urodyn. 2015, 34, 86.

Application

Reagent for nausea or vomiting model

References

Cisplatin-induced emesis in the Ferret: a new animal model.
- A. P. Florczyk, J. E. Schurig, W. T. Bradner, Cancer Treat Rep. 1982, 66, 1, 187-189.
The anti-cancer drug-induced pica in rats is related to their clinical emetogenic potential.
- K. Yamamoto, M. Nakai, K. Nohara, A. Yamatodani, Eur. J .Pharmacol. 2007, 554, 1, 34-39.

Application

Reviews on the Biochemical Mechanisms of Action of Cisplatin

References

Structure, recognition, and processing of cisplatin-DNA adducts
- E. R. Jamieson, S. J. Lippard, Chem. Rev. 1999, 99, 2467.
Why does cisplatin reach guanine-N7 with competing S-donor ligands available in the cell?
- J. Reedijk, Chem. Rev. 1999, 99, 2499.
Biochemical modulation of cisplatin mechanisms of action: enhancement of antitumor activity and circumvention of drug resistance
- M. A. Fuertes, C. Alonso, J. M. Perez, Chem. Rev. 2003, 103, 645.
Cisplatin: mode of cytotoxic action and molecular basis of resistance
- Z. H Siddik, Oncogene 2003, 22, 7265.
Cellular responses to cisplatin. The roles of DNA-binding proteins and DNA repair.
- G. Chu. J. Biol. Chem. 1994, 269, 787.
Cellular processing of platinum anticancer drugs
- D. Wang, S. J. Lippard, Nat. Rev. Drug Discovery 2005, 4, 307.

PubMed Literature

Size	Unit Price	Shanghai	Tianjin	Japan*
100MG	¥560.00	Contact Us	1	≥40
250MG	¥990.00	Contact Us	Contact Us	Contact Us
1G	¥2,090.00	2	1	≥40

CAS RN: 15663-27-1 | Product Number: D3371

cis-Diammineplatinum(II) Dichloride

Reference

References

References

References

References

Articles/Brochures

Safety Data Sheet (SDS)

Specifications

C of A & Other Certificates

Sample C of A

Analytical Charts

Other Documents

Product Categories

Life Science

Chemicals by Class

Chemistry

Life Science

Chemicals by Class

Chemistry

How To Order

About TCI