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CAS RN: 555-30-6 | Product Number: D1817
3-(3,4-Dihydroxyphenyl)-2-methyl-L-alanine Sesquihydrate
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Purity: >98.0%(T)(HPLC)
Synonyms:
- α-Methyl-L-DOPA Sesquihydrate
- Methyldopa Sesquihydrate
Product Documents:
| Size | Unit Price | Shanghai | Tianjin | Japan* |
|---|---|---|---|---|
| 5G |
¥250.00
|
2 | 1 | 4 |
| 25G |
¥990.00
|
2 | 1 | 6 |
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| Product Number | D1817 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__0H__1__3NO__4·1^^1/__2H__2O = 238.24 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Light Sensitive,Air Sensitive |
| CAS RN | 555-30-6 |
| Related CAS RN
|
41372-08-1 |
| Reaxys Registry Number | 2807721 |
| PubChem Substance ID | 87568286 |
| Merck Index (14) | 6055 |
| MDL Number | MFCD00004186 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 %(calcd.on anh.substance) |
| Specific rotation [a]20/D | -12.5 to -14.5 deg(C=1, H2O) |
| Solubility in hot Water | almost transparency |
| Water | 10.0 to 12.0 % |
| NMR | confirm to structure |
Properties (reference)
| Specific Rotation | -14° (C=1,H2O) |
GHS
| Signal Word | Warning |
| Hazard Statements | H303 : May be harmful if swallowed. |
| Precautionary Statements | P312 : Call a POISON CENTER/doctor if you feel unwell. |
Related Laws:
| RTECS# | AY5950000 |
Transport Information:
| Customs Control Conditions (Q) |
Application
Methyldopa: An Aromatic-Amino Acid Decarboxylase Inhibitor
Methyldopa is an aromatic-amino acid decarboxylase inhibitor. It inhibits the decarboxylation of L-DOPA [D0600], thereby interfering with the formation of dopamine [A0305 (HCl salt)], a precursor of L-norepinephrine [A0906 (bitartrate)]. Methyldopa is an effective anti-hypertensive agent that reduces both supine and standing blood pressure. At first, the anti-hypertensive activity was believed to be related with the inhibition. Nowadays, methyldopa is metabolized to α-methylnorepinephrine and this compound is thought to stimulate central nerve α-adrenergic receptors, producing a decrease in peripheral sympathetic outflow, and resulting in decreasing blood pressure. (The product is for research purpose only.)
References
- Studies on the metabolism and mechanism of action of methyldopa
- α-Sympathetic receptor stimulation in the brain and hypotensive activity of α-methyldopa
- Clinical pharmacokinetics of methyldopa (a review)
- Spectrophotometric determination of methyldopa in pure and pharmaceutical preparations
- Simultaneous determination of serum concentrations of levodopa, dopamine, 3-O-methyldopa and α-methyldopa by HPLC
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