Maximum quantity allowed is 999
CAS RN: 74124-79-1 | Product Number: D1662
Di(N-succinimidyl) Carbonate
Purity: >98.0%(T)
- N-Succinimidyl Carbonate
- N,N'-Disuccinimidyl Carbonate
- DSC
| Size | Unit Price | Shanghai | Tianjin | Japan* |
|---|---|---|---|---|
| 5G |
¥645.00
|
7 | 4 | ≥80 |
| 25G |
¥1,590.00
|
8 | 1 | 13 |
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| Product Number | D1662 |
| Purity / Analysis Method | >98.0%(T) |
| Molecular Formula / Molecular Weight | C__9H__8N__2O__7 = 256.17 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Moisture Sensitive,Heat Sensitive |
| CAS RN | 74124-79-1 |
| Reaxys Registry Number | 1499137 |
| PubChem Substance ID | 87568139 |
| MDL Number | MFCD00009767 |
| Appearance | White to Light gray to Light yellow powder to crystal |
| Purity(Butylamine Method) | min. 98.0 % |
| Melting Point | 215 °C(dec.) |
| Solubility in water | Insoluble |
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
| Customs Control Conditions (Q) |
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Used Chemicals
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Procedure
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To a solution of compound 3-(3,4-dimethoxyphenyl)propionic acid (0.10 g, 0.48 mmol), di(N-succinimidyl) carbonate (0.19 g, 0.62 mmol) in dichloromethane (5.0 mL) was added triethylamine (0.086 mL, 0.62 mmol) at ambient temperature and stirred at same temperature for 30 minutes. The mixture was added 4-methylbenzylamine (0.078 mL, 0.62 mmol) and stirred at same temperature for 1 hour. After completion of the reaction, the solvent was removed under reduced pressure and the residue was purified by column chromatography (ethyl acetate:hexane = 3:7 - 1:1 on silica gel) to give 1 (0.13 g，y. 86%) as a white solid.
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Experimenter’s Comments
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The reaction mixture was monitored by UPLC.
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Analytical Data
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compound 1
1H NMR (400 MHz, CDCl3); δ 7.10 (2H, d, J = 8.0 Hz), 7.05 (2H, d, J = 8.0 Hz), 6.78-6.70 (3H, m), 5.58 (1H, brs), 4.36 (2H, d, J = 5.6 Hz), 3.85 (3H, s), 3.83 (3H, s), 2.94 (2H, t, J = 7.6 Hz), 2.48 (2H, t, J = 7.6 Hz), 2.32 (3H, s).
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Lead Reference
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- A novel active ester synthesis reagent (N,N’-disuccinimidyl carbonate)
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Other References
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- Studies on Lactams IX. A Convenient Synthesis of Lactam Rings
- Synthesis and Reactivity Comparisons of 1-Methyl-3-Substituted Cyclopropene Mini-tags for Tetrazine Bioorthogonal Reactions
References
- 1)A novel active ester synthesis reagent (N,N’-disuccinimidyl carbonate)
- 2)Studies on Lactams IX. A Convenient Synthesis of Lactam Rings
- 3)Synthesis and Reactivity Comparisons of 1-Methyl-3-Substituted Cyclopropene Mini-tags for Tetrazine Bioorthogonal Reactions
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