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CAS RN: 6020-18-4 | Product Number: C3719
Coptisine Chloride
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Purity: >95.0%(T)(HPLC)
Synonyms:
- 7,8,13,13a-Tetradehydro-2,3:9,10-bis(methylenedioxy)berbinium Chloride
- 6,7-Dihydrobis[1,3]benzodioxolo[5,6-a:4',5'-g]quinolizinium Chloride
- 6,7-Dihydro-[1,3]dioxolo[4',5':7,8]isoquinolino[3,2-a][1,3]dioxolo[4,5-g]isoquinolin-5-ium Chloride
Product Documents:
| Size | Unit Price | Shanghai | Tianjin | Japan* |
|---|---|---|---|---|
| 25MG |
¥460.00
|
3 | Contact Us | 9 |
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| Product Number | C3719 |
| Purity / Analysis Method | >95.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__9H__1__4NO__4Cl = 355.77 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Hygroscopic |
| CAS RN | 6020-18-4 |
| Reaxys Registry Number | 4118452 |
| MDL Number | MFCD00016676 |
Specifications
| Appearance | Light yellow to Yellow to Orange powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(Precipitation Titration) | min. 95.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 218 °C |
GHS
Related Laws:
Transport Information:
| Customs Control Conditions (Q) | Q类 （糖类，生物碱类，抗生素类，激素类） |
Application
Coptisine Chloride: A Protoberberine Alkaloid with a Wide Range of Pharmacological and Biological Activities
Coptisine chloride, a protoberberine alkaloid, is widely found in traditional Chinese medicinal plants including Coptis rhizome, Ranunculaceae and Papaveraceae plants. There are reports that coptisine chloride has a wide range of pharmacological and biological activities.1-3) Recently, coptisine chloride has also been attracting attention on its activity against central nervous system disorders, such as improving the symptoms of Alzheimer’s disease.4) (The product is for research purpose only.)
References
- 1) Cytotoxic effects of Coptis chinensis and Epimedium sagittatum extracts and their major constituents (berberine, coptisine and icariin) on hepatoma and leukaemia cell growth
- 2) Selective inhibition of vascular smooth muscle cell proliferation by coptisine isolated from Coptis rhizoma, one of the crude drugs composing Kampo medicines Unsei-in
- 3) Coptisine protects rat heart against myocardial ischemia/reperfusion injury by suppressing myocardial apoptosis and inflammation
- 4) Anti-alzheimer and antioxidant activities of coptidis Rhizoma alkaloids
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