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CAS RN: 32222-06-3 | Product Number: C3078
Calcitriol
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Purity: >97.0%(HPLC)
Synonyms:
- 1α,25-Dihydroxyvitamin D3
- 1,25-Dihydroxycholecalciferol
Product Documents:
| Size | Unit Price | Shanghai | Tianjin | Japan* |
|---|---|---|---|---|
| 1MG |
¥3,300.00
|
2 | Contact Us | Contact Us |
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| Product Number | C3078 |
| Purity / Analysis Method | >97.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__7H__4__4O__3 = 416.65 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (<0°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 32222-06-3 |
| Reaxys Registry Number | 2227647 |
| PubChem Substance ID | 354333875 |
| Merck Index (14) | 1644 |
| MDL Number | MFCD00867079 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
Properties (reference)
| Melting Point | 119 °C |
| Maximum Absorption Wavelength | 265 nm |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H300 + H310 + H330 : Fatal if swallowed, in contact with skin or if inhaled. H361 : Suspected of damaging fertility or the unborn child. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P262 : Do not get in eyes, on skin, or on clothing. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P271 : Use only outdoors or in a well-ventilated area. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P284 : Wear respiratory protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P361 + P364 : Take off immediately all contaminated clothing and wash it before reuse. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P302 + P352 + P310 : IF ON SKIN: Wash with plenty of water. Immediately call a POISON CENTER/doctor. P304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor. P403 + P233 : Store in a well-ventilated place. Keep container tightly closed. P405 : Store locked up. |
Related Laws:
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | I |
| Customs Control Conditions (Q) |
Application
Calcitriol: The Active Form of Vitamin D3
Calcitriol (1α,25-dihydroxyvitamin D3) is the active form of vitamin D3 (cholecalciferol) [C0314]. The natural supply of vitamin D3 in human being mainly depends on ultraviolet light for conversion of 7-dehydrocholesterol [CAS: 434-16-2] to vitamin D3 in the skin. The transformation (hydroxylation) of vitamin D3 is catalyzed by enzymes in the liver and the kidney to produce calcitriol, the active form of vitamin D3. Calcitriol is active in the regulation of the absorption of calcium from the gastrointestinal tract. In addition, in vitro and in vivo studies have shown that calcitriol directly suppresses secretion and synthesis of parathyroid hormone (PTH). (The product is for research purpose only.)
References
- 5'-Flanking region of the parathyroid hormone gene mediates negative regulation by 1,25-(OH)2 vitamin D3
- Cloning and characterization of an extracellular Ca2+-sensing receptor from bovine parathyroid
- Structure-function relationships in the vitamin D endocrine system (a review)
- The nuclear vitamin D receptor: biological and molecular regulatory properties revealed (a review)
- Current understanding of the molecular actions of vitamin D (a review)
- Vitamin D (a review)
- Vitamin D and human health: lessons from vitamin D receptor null mice (a review)
PubMed Literature
Articles/Brochures
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