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CAS RN: 98753-19-6 | Product Number: C3007
Cefpirome Sulfate
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Purity: >95.0%(HPLC)(N)
Synonyms:
Product Documents:
| Size | Unit Price | Shanghai | Tianjin | Japan* |
|---|---|---|---|---|
| 1G |
¥390.00
|
3 | 1 | 2 |
| 5G |
¥1,695.00
|
2 | Contact Us | 9 |
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Supplemental Product Information:
This product has not been tested for potency and is guaranteed for chemical purity.
| Product Number | C3007 |
| Purity / Analysis Method | >95.0%(HPLC)(N) |
| Molecular Formula / Molecular Weight | C__2__2H__2__2N__6O__5S__2·H__2SO__4 = 612.65 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Hygroscopic,Heat Sensitive |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 98753-19-6 |
| Related CAS RN | 84957-29-9 |
| Reaxys Registry Number | 11738005 |
| PubChem Substance ID | 253661002 |
| Merck Index (14) | 1940 |
| MDL Number | MFCD11864966 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(with Total Nitrogen) | min. 95.0 % |
| Specific rotation [a]20/D | -27.0 to -33.0 deg(C=2.5,a solution prepared by addition of water to 25mL of actonitrile to make 50mL)(calcd.on anh.substance) |
| Water | max. 5.0 % |
Properties (reference)
| Melting Point | 200 °C |
| Specific Rotation | -30° (C=2.5,JP Method) |
| Maximum Absorption Wavelength | 265(Buffer) nm |
| Solubility in water | Soluble |
| Solubility (insoluble in) | Ether, Ethanol |
GHS
Related Laws:
| RTECS# | UW8970000 |
Transport Information:
| Customs Control Conditions (Q) | Q类 （糖类，生物碱类，抗生素类，激素类） |
Application
Cefpirome: A Fourth Generation Cephalosporin with Broad Spectrum of Activity and Stability to β-Lactamases
Cefpirome sulfate is a fourth generation semi-synthetic cephalosporin. It has a broad spectrum of activity against Gram-positive and Gram-negative aerobic and anaerobic bacteria, and is generally more active against Gram-negative bacteria than the first and second generation cephalosporins. While the mechanism of action similar to other cephalosporins (inhibition of peptidoglycan synthesis by cell walls), cefpirome has also activity against Gram-positive coccus (eg. Streptococcus pneumoniae) more than the third generation cephalosporins, regardless of penicillin susceptibility. And it has increased stability to β-lactamases compared with the first and second generation cephalosporins.
References
- Stability and degradation pattern of cefpirome (HR 810) in aqueous solution
- Comparative study of pharmacokinetics and serum bactericidal activities of cefpirome, ceftazidime, ceftriaxone, imipenem, and ciprofloxacin
- Cefpirome: a review of its antibacterial activity, pharmacokinetic properties and clinical efficacy in the treatment of severe nosocomial infections and febrile neutropenia
- Development of an analytical method for cefpirome in plasma by simplified HPLC technique and its applications
- Stability-Indicating HPLC and RP-TLC Determination of Cefpirome Sulfate with Kinetic Study
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