Product Number	C2481
Purity / Analysis Method	>98.0%(T)(HPLC)
Molecular Formula / Molecular Weight	C₁₇H₁₉ClN₂S·HCl = 355.32
Physical State (20 deg.C)	Solid
Storage Temperature	Room Temperature (Recommended in a cool and dark place, <15°C)
Condition to Avoid	Light Sensitive
CAS RN	69-09-0
Related CAS RN	50-53-3
Reaxys Registry Number	3779989
PubChem Substance ID	125307954
Merck Index (14)	2185
MDL Number	MFCD00012654

Specifications

Appearance	White to Almost white powder to crystal
Purity(HPLC)	min. 98.0 area%
Purity(Nonaqueous Titration)	min. 98.0 %
Melting point	195.0 to 199.0 °C

Properties (reference)

Melting Point	197 °C
Solubility in water	Soluble
Solubility (soluble in)	Methanol, Ethanol
Solubility (insoluble in)	Ether, Benzene

GHS

Pictogram
Signal Word	Danger
Hazard Statements	H330 : Fatal if inhaled. H301 : Toxic if swallowed.
Precautionary Statements	P501 : Dispose of contents/ container to an approved waste disposal plant. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P271 : Use only outdoors or in a well-ventilated area. P264 : Wash skin thoroughly after handling. P284 : Wear respiratory protection. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor. P403 + P233 : Store in a well-ventilated place. Keep container tightly closed. P405 : Store locked up.

Related Laws:

RTECS#

SO1750000

Transport Information:

UN Number	UN2811
Class	6.1
Packing Group	I
Customs Control Conditions (Q)

Application

Biofilm research

References

Antifungal activity of promethazine and chlorpromazine against planktonic cells and biofilms of Cryptococcus neoformans/Cryptococcus gattii complex species

R.S.N. Brilhante, W.J.P. Gotay, V.S. Pereira, J.S. de Oliveira, W.A. Pereira-Neto, D.S.C.M. Castelo-Branco, R.A. Cordeiro, J.J.C. Sidrim, M.F.G. Rocha, Med. Mycol. 2020, 58, 906.

Laser-Irradiated Chlorpromazine as a Potent Anti-Biofilm Agent for Coating of Biomedical Devices

S. Nistorescu, G.G. Pircalabioru, A.M. Udrea, A. Simon, M.L. Pascu, M.-C. Chifiriuc, Coatings 2020, 10, 1230.

Application

Chlorpromazine Hydrochloride: A Dopamine Inhibitor with Antipsychotic Activity

Chlorpromazine hydrochloride is a phenothiazine antipsychotic agent. The precise mechanism of actions is not fully understood. However, chlorpromazine works as a dopamine inhibitor, and the antagonism central dopaminergic function may be related to the therapeutic effect in psychotic conditions. Chlorpromazine can also produce α-adrenergic receptor antagonist action which may produce hypotension. Besides, it is reported that UV irradiation of chlorpromazine produces reactive free radicals which have DNA damaging properties. (The product is for research purpose only.)

References

Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs
- I. Creese, D. R. Burt, S. H. Snyder, Science 1976, 192, 481.
Expression and pharmacological characterization of the human D₃ dopamine receptor
- S. B. Freedman, S. Patel, R. Marwood, F. Emms, G. R. Seabrook, M. R. Knowles, G. McAllister, J. Pharmacol. Exp. Ther. 1994, 268, 417.
Unique binding characteristics of antipsychotic agents interacting with human dopamine D_2A, D_2B, and D₃ receptors
- A. Malmberg, D. M. Jackson, A. Eriksson, N. Mohell, Mol. Pharmacol. 1993, 43, 749.
Review of the genotoxic properties of chlorpromazine and related phenothiazines
- E. Gocke, Mutat. Res. Rev. Genet. Toxicol. 1996, 366, 9.
Fifty years chlorpromazine: a historical perspective (a review)
- T. A. Ban, Neuropsychiatr. Dis. Treat. 2007, 3, 495.
Simple and simultaneous determination for 12 phenothiazines in human serum by reversed-phase high-performance liquid chromatography
- E. Tanaka, T. Nakamura, M. Terada, T. Shinozuka, C. Hashimoto, K. Kurihara, K. Honda, J. Chromatogr. B 2007, 854, 116.
Extraction and determination of trace amounts of chlorpromazine in biological fluids using hollow fiber liquid phase microextraction followed by high-performance liquid chromatography
- H. R. Sobhi, Y. Yamini, R. H. H. B. Abadi, J. Pharm. Biomed. Anal. 2007, 45, 769.

PubMed Literature

Size	Unit Price	Shanghai	Tianjin	Japan*
5G	¥140.00	27	Contact Us	≥100
25G	¥620.00	2	Contact Us	≥40

CAS RN: 69-09-0 | Product Number: C2481

Chlorpromazine Hydrochloride

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