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CAS RN: 174635-69-9 | Product Number: B6551
SB 222200
×
Purity: >98.0%(HPLC)
Synonyms:
- 3-Methyl-2-phenyl-N-[(1S)-1-phenylpropyl]-4-quinolinecarboxamide
- (S)-3-Methyl-2-phenyl-N-(1-phenylpropyl)quinoline-4-carboxamide
Product Documents:
| Size | Unit Price | Shanghai | Tianjin | Japan* |
|---|---|---|---|---|
| 10MG |
¥80.00
|
4 | Contact Us | ≥80 |
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| Product Number | B6551 |
Purity / Analysis Method 
|
>98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__6H__2__4N__2O = 380.49 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 174635-69-9 |
| Reaxys Registry Number | 7546636 |
| MDL Number | MFCD00944072 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 153.0 to 157.0 °C |
| Specific rotation | -35.0 to -39.0 deg(C=0.5, methanol) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 155 °C |
GHS
Related Laws:
| RTECS# | VB1174632 |
Transport Information:
| Customs Control Conditions (Q) |
Application
SB 222200: An Orally Active 2-Phenylquinoline Framework Based Neurokinin-3 (NK3) Receptor Antagonist
SB 222200 is an orally active 2-phenylquinoline framework based neurokinin-3 (NK3) receptor antagonist with high affinity, selectivity, reversibility and central nervous system penetration. It is selective for NK3 over NK1 and NK2 receptors. (The product is for research purpose only.)
References
- Nonpeptide tachykinin receptor antagonists. II. Pharmacological and pharmacokinetic profile of SB-222200, a central nervous system penetrant, potent and selective NK-3 receptor antagonist
- Central anti-hypertensive effect of tachykinin NK3 receptor antagonists in rat
- 2-Phenyl-4-quinolinecarboxamides: A Novel Class of Potent and Selective Non-Peptide Competitive Antagonists for the Human Neurokinin-3 Receptor
Product Documents (Note: Some products will not have analytical charts available.)
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