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CAS RN: 207857-15-6 | Product Number: B3625
1,3-Bis(tert-butoxycarbonyl)-2-(trifluoromethanesulfonyl)guanidine
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 1,3-Di-Boc-2-(trifluoromethanesulfonyl)guanidine
- 1,3-Bis(tert-butoxycarbonyl)-2-(trifluoromethylsulfonyl)guanidine
- 1,3-Di-Boc-2-(trifluoromethylsulfonyl)guanidine
- Goodman's Reagent
Product Documents:
| Size | Unit Price | Shanghai | Tianjin | Japan* |
|---|---|---|---|---|
| 1G |
¥350.00
|
Contact Us | Contact Us | 17 |
| 5G |
¥1,390.00
|
Contact Us | Contact Us | 8 |
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| Product Number | B3625 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__2H__2__0F__3N__3O__6S = 391.36 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 207857-15-6 |
| Reaxys Registry Number | 7947176 |
| PubChem Substance ID | 125307766 |
| MDL Number | MFCD02683528 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
Properties (reference)
| Melting Point | 113 °C(dec.) |
| Solubility (soluble in) | Methanol |
GHS
Related Laws:
Transport Information:
| Customs Control Conditions (Q) |
Application
Goodman’s Reagent: A Guanidinylating Reagent
Experimental procedure1): the amine (0.5 mmol) is added neat to a solution of 1,3-bis(tert-butoxycarbonyl)-2-(trifluoromethanesulfonyl)guanidine (1, 0.45 mmol) and triethylamine (70 µL, 0.5 mmol) in dichloromethane (2 mL), and the mixture is stirred at rt until all 1 is consumed as evidenced by TLC. After completion of the reaction, the mixture is diluted with dichloromethane (3 mL) and washed with 2 mol/L sodium bisulfate, saturated sodium bicarbonate, and brine. After drying with sodium sulfate and filtering the solvent is removed under reduced pressure. If desired, the crude products may be further purified by flash chromatography.
References
- 1)Diprotected Triflylguanidines: A New Class of Guanidinylation Reagents
- 2)Synthesis of Guanidines From Azides: A General and Straightforward Methodology In Carbohydrate Chemistry
Application
Goodman’s Reagent: A Guanidinylating Reagent
Experimental procedure1): the amine (0.5 mmol) is added neat to a solution of 1,3-bis(tert-butoxycarbonyl)-2-(trifluoromethanesulfonyl)guanidine (1, 0.45 mmol) and triethylamine (70 µL, 0.5 mmol) in dichloromethane (2 mL), and the mixture is stirred at rt until all 1 is consumed as evidenced by TLC. After completion of the reaction, the mixture is diluted with dichloromethane (3 mL) and washed with 2 mol/L sodium bisulfate, saturated sodium bicarbonate, and brine. After drying with sodium sulfate and filtering the solvent is removed under reduced pressure. If desired, the crude products may be further purified by flash chromatography.
References
- 1) Diprotected Triflylguanidines: A New Class of Guanidinylation Reagents
- 2) Synthesis of Guanidines From Azides: A General and Straightforward Methodology In Carbohydrate Chemistry
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