CAS RN: 71042-54-1 | Product Number: B3450

(2S,3S)-(+)-2,3-Bis(diphenylphosphino)bicyclo[2.2.1]hept-5-ene

Purity: >98.0%(GC)

Synonyms:

(2S,3S)-(+)-Norphos

Product Documents:

Size	Unit Price	Shanghai	Tianjin	Japan*
100MG	¥975.00	1	1	5

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General Information plus

Product Number	B3450
Purity / Analysis Method	>98.0%(GC)
Molecular Formula / Molecular Weight	C__3__1H__2__8P__2 = 462.51
Physical State (20 deg.C)	Solid
Storage Temperature	Room Temperature (Recommended in a cool and dark place, <15°C)
CAS RN	71042-54-1
Reaxys Registry Number	5306483
PubChem Substance ID	87561492
MDL Number	MFCD00085364

Specifications & Documents plus

Specifications

Appearance	White to Almost white powder to crystal
Purity(GC)	min. 98.0 %
Specific rotation [a]20/D	+45.0 to +51.0 deg(C=1, CHCl3)
NMR	confirm to structure

Properties (reference)

Melting Point	130 °C
Specific Rotation	50° (C=1,CHCl3)

Safety & Properties plus

GHS

Pictogram
Signal Word	Warning
Hazard Statements	H315 : Causes skin irritation. H319 : Causes serious eye irritation.
Precautionary Statements	P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention.

Related Laws:

Transport Information:

Customs Control Conditions (Q)

Applications & Literature plus

Application

Asymmetric hydrogenation with rhodium catalyst

Typical procedure: (2S,3S)-(+)-Norphos (3.7 mg) and [Rh(cod)Cl]2 (4 mg) were stirred in methanol (5 mL) in a hydrogen atmosphere for 15 min, giving an orange solution. (Z)-2-Benzamido-3-ferrocenylacrylic acid (1)(3.76 g) was dissolved in methanol (20 mL) and the catalytic orange solution was added under nitrogen. Then, the reaction vessel was vented three times with hydrogen. Hydrogenation at 1.1 atm proceeded at room temperature and was stopped after 3.5 d, when the hydrogen uptake was complete. After the hydrogenation, the solvent was evaporated and the residue was treated with 1N NaOH (2.5 mL) for 30 min. The solution was filtered, diluted with water (20 mL), acidified with 1N HCl and extracted with ether. The organic phase was dried over Na2SO4 and concentrated to dryness to give (2R)-2-benzamido-3-ferrocenylpropanic acid (2)(3.4 g, 90 %, 91.3 94.9 % ee) as yellow solid.