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CAS RN: 118458-54-1 | Product Number: A3497
Arcyriaflavin A
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Purity: >90.0%(HPLC)(qNMR)
Synonyms:
- 12,13-Dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
- Maleimide Indolocarbazole
Product Documents:
| Size | Unit Price | Shanghai | Tianjin | Japan* |
|---|---|---|---|---|
| 20MG |
¥1,990.00
|
Contact Us | Contact Us | 26 |
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| Product Number | A3497 |
| Purity / Analysis Method | >90.0%(HPLC)(qNMR) |
| Molecular Formula / Molecular Weight | C__2__0H__1__1N__3O__2 = 325.33 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (-20°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 118458-54-1 |
| Reaxys Registry Number | 4557421 |
| MDL Number | MFCD03452662 |
Specifications
| Appearance | Light yellow to Yellow to Orange powder to crystal |
| Purity(HPLC) | min. 90.0 area% |
| Purity(qNMR) | min. 90.0 % |
| NMR | confirm to structure |
Properties (reference)
GHS
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Application
Arcyriaflavin A: A Potent Inhibitor of Protein Kinases
Arcyriaflavin A is an important member of the indolocarbazole alkaloid family, and was first isolated in 1980 from the slime mold Arcyria denudata.1) This family has potential therapeutic application in the treatment of cancer because of its ability to inhibit protein kinases.2,3) Thera are reports that arcyriaflavin A inhibits cyclin-dependent kinase 4 (CDK49 and calcium/calmodulin-dependent protein kinase II (CaMKII).3,4) It also inhibits proliferation and induces apoptosis of endometriotic cyst stromal cells (ECSCs).5) In addition, arcyriaflavin A has been used a key synthetic intermediate of indolocarbazole alkaloids such as staurosporinone [T4000] which is a protein kinase C (PKC) and leucine-rich repeat kinase 2 (LRRK2) inhibitor.6) (The product is for research purpose only.)
References
- 1) Indole Pigments from the Fruiting Bodies of the Slime Mold Arcyria denudata
- 2) Indolocarbazole natural products: occurrence, biosynthesis, and biological activity
- 3) Arcyriaflavin A monohydrate
- 4) Aryl[a]pyrrolo[3,4-c]carbazoles as selective cyclin D1-CDK4 inhibitorss
- 5) Arcyriaflavin a, a cyclin D1–cyclin-dependent kinase4 inhibitor, induces apoptosis and inhibits proliferation of human endometriotic stromal cells: a potential therapeutic agent in endometriosis
- 6) An account of synthetic strategies towards indolocarbazole alkaloids: Arcyriaflavin A and staurosporinone (a review)
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