Maximum quantity allowed is 999
Please select the quantity
CAS RN: 181183-52-8 | Product Number: A3111
Almotriptan Malate
×
![]()
×
Purity: >98.0%(HPLC)
Synonyms:
- 3-[2-(Dimethylamino)ethyl]-5-(pyrrolidin-1-ylsulfonylmethyl)-1H-indole Malate
Product Documents:
| Size | Unit Price | Shanghai | Tianjin | Japan* |
|---|---|---|---|---|
| 25MG |
¥115.00
|
1 | Contact Us | 1 |
| 100MG |
¥275.00
|
Contact Us | Contact Us | 30 |
* For order or inquiry, please contact
Our Authorized Distributors.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
* To send your quote request for bulk quantities, please click on the "Request Bulk Quote" button. Please note that we cannot offer bulk quantities for some products.
| Product Number | A3111 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__7H__2__5N__3O__2S·C__4H__6O__5 = 469.55 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 181183-52-8 |
| Related CAS RN | 154323-57-6 |
| Reaxys Registry Number | 15435698 |
| PubChem Substance ID | 468590147 |
| Merck Index (14) | 304 |
| MDL Number | MFCD08067740 |
Specifications
| Appearance | White to Orange to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Elemental analysis(Nitrogen) | 8.50 to 9.50 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 162 °C(dec.) |
| Solubility in water | Soluble |
GHS
Related Laws:
Transport Information:
| Customs Control Conditions (Q) |
Application
Almotriptan Malate: A Selective 5-HT1B/1D Receptor Agonist
Almotriptan malate is a selective 5-hydroxytryptamine1B/1D (5-HT1B/1D) receptor agonist, known as triptan. Almotriptan binds with high affinity to 5-HT1B, 5-HT1D, and 5-HT1F receptors, and has weak affinity for 5-HT1A and 5-HT7 receptors. However, almotriptan has no significant affinity at 5-HT2, 5-HT3, 5-HT4 or 5-HT6. Triptans, including almotriptan, are major advance in the treatment of migraine. The therapeutic activity of triptans in migramine can most likely to be attributed to agonist effects at 5-HT1B/1D receptors on the intracranial blood vessels. (The product is for research purpose only.)
References
- Pharmacological characterization of almotriptan: an indolic 5-HT receptor agonist for the treatment of migraine
- Almotriptan, a New Anti‐Migraine Agent: A Review
- Triptans in migraine: A comparative review of pharmacology, pharmacokinetics and efficacy
- A validated reversed phase HPLC method for the determination of process-related impurities in almotriptan malate active pharmaceutical ingredient
- A validated RP HPLC method for estimation of almotriptan malate in pharmaceutical dosage form
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
Please select Language.
The requested SDS is not available.
Please Contact Us for more information.
Specifications
C of A & Other Certificates
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
Sample C of A
This is a sample C of A and may not represent a recently manufactured lot of the product.
A sample C of A for this product is not available at this time.
Analytical Charts
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
The requested analytical chart is not available. Sorry for the inconvenience.