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Albumin Binding Modification Reagents
In pharmaceuticals, pharmacokinetics is one of the important factors for drug efficacy. Pharmacokinetics of drugs and contrast agents is optimized by introducing fatty acids and Diphenylcyclohexane derivatives which have affinity with human serum albumin. Recently, several insulin drugs having a regulated half-life in blood by modification with fatty acids such as myristic acid or palmitic acid have been developed and approved. These reagents are expected to be available for optimization of pharmacokinetics with peptides generally having a short half-life in blood.
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References
- Fatty acid binding to plasma albumin
- Soluble, fatty acid acylated insulins bind to albumin and show protracted action in pigs
- Phosphate Ester Serum Albumin Affinity Tags Greatly Improve Peptide Half-Life In Vivo
