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Published TCIMAIL newest issue No.197
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CAS RN: 100-97-0 | Product Number: H0093
Hexamethylenetetramine
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Purity: >99.0%(GC)(T)
Synonyms:
- 1,3,5,7-Tetraazaadamantane
- HMTA
- Urotropine
- Methenamine
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 25G |
£16.00
|
Contact Us | ≥100 |
|
| 500G |
£29.00
|
18 | ≥100 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | H0093 |
| Purity / Analysis Method | >99.0%(GC)(T) |
| Molecular Formula / Molecular Weight | C__6H__1__2N__4 = 140.19 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 100-97-0 |
| Reaxys Registry Number | 2018 |
| PubChem Substance ID | 87570541 |
| SDBS (AIST Spectral DB) | 1331 |
| Merck Index (14) | 5966 |
| MDL Number | MFCD00006895 |
Specifications
| Appearance | White powder to crystal |
| Purity(GC) | min. 99.0 % |
| Purity(Nonaqueous Titration) | min. 99.0 % |
| Solubility in Water | almost transparency |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 280 °C |
| Degree of solubility in water | 448,600 mg/l 12 °C |
| Solubility (soluble in) | Alcohol, Chloroform |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H302 : Harmful if swallowed. H361 : Suspected of damaging fertility or the unborn child. H372 : Causes damage to organs through prolonged or repeated exposure. H317 : May cause an allergic skin reaction. H341 : Suspected of causing genetic defects. H228 : Flammable solid. |
| Precautionary Statements | P260 : Do not breathe dust. P210 : Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P370 + P378 : In case of fire: Use dry sand, dry chemical or alcohol-resistant foam to extinguish. |
Related Laws:
| EC Number | 202-905-8 |
| RTECS# | MN4725000 |
Transport Information:
| UN Number | UN1328 |
| Class | 4.1 |
| Packing Group | III |
| HS Number | 2933998090 |
Application
TCI Practical Example: Formylation Using Hexamethylenetetramine (= Duff reaction)
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Used Chemicals
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- 2,6-Dimethylphenol [D0776]
- Hexamethylenetetramine [H0093]
- Trifluoroacetic Acid (= TFA)
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Procedure
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A solution of 2,6-dimethylphenol (500 mg, 4.1 mmol) and hexamethylenetetramine (574 mg, 4.1 mmol) in TFA (5 mL) was stirred under nitrogen at 80 ˚C for 1.5 hours. The reaction was quenched with water and extracted with diethyl ether. The organic phase was dried over anhydrous sodium sulfate and filtered. The solvent was removed under reduced pressure to give 4-hydroxy-3,5-dimethylbenzaldehyde as a yellow solid (446 mg, 73% yield).
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Analytical Data
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The reaction mixture was monitored by NMR.
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Analytical Data
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4-Hydroxy-3,5-dimethylbenzaldehyde
1H NMR (270 MHz, CDCl3); δ 9.81 (s, 1H), 7.55 (s, 2H), 5.28 (bs, 1H), 2.31 (s, 6H).
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Lead Reference
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- Electronic-State Switching Strategy in the Photochemical Synthesis of Indanones from o-Methyl Phenacyl Epoxides
Application
Duff Reaction
References
- Electronic-State Switching Strategy in the Photochemical Synthesis of Indanones from o-Methyl Phenacyl Epoxides
PubMed Literature
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