text.skipToContent text.skipToNavigation

Maximum quantity allowed is 999

Bitte wählen Sie die Menge aus.

Products > Featured Products >

Base-modified Ribonucleoside Triphosphates for mRNA Drug Discovery

RNA base-modified ribonucleoside triphosphate is used in in vitro transcription (IVT) of RNA medicines. RNA vaccines work by inducing the body to express viral proteins, which in turn stimulate the immune system to produce antibodies. In this process, the mRNA's own evasion of the immune system is important, along with the mRNA's translational efficiency. It is known that swapping nucleotides for a related analogue helped to make the mRNA less conspicuous to the immune system.1)
TCI has commercialized N1-methyl pseudouridine 5'-triphosphate sodium salt (Product No. M3544), pseudouridine 5'-triphosphate sodium salt (Product No. P3045), 5-methyluridine 5'-triphosphate sodium salt (Product No. M3582), 5-methylcytidine 5'-triphosphate sodium salt (Product No. M3583), 5-methoxyuridine 5'-triphosphate sodium salt (Product No. M3584) which are expected to have high translational efficiency and immunogenicity reduction effects, as raw materials for the synthesis of modified RNA medicines.2-6) These products have been checked for DNase and RNase contamination and functionality in IVT.

In recent years, studies in this field have been very active, new effects of base-modified nucleotides are continuously being reported. TCI is capable of performing the full process from modification of bases to triphosphorylation in-house, and can also provide base-modified triphosphates that are not listed in our catalog. TCI are also available for consultation on scale-up manufacturing.

Products

Page Top

References

Page Top

Sitzungsstatus
Ihre Sitzung wird in 10 Minuten beendet. Sie werden nach dem Ablauf der Sitzung auf die Startseite umgeleitet. Bitte klicken Sie auf die Schaltfläche, um die Sitzung auf derselben Seite fortzusetzen. Minute beendet. Sie werden nach dem Ablauf der Sitzung auf die Startseite umgeleitet. Bitte klicken Sie auf die Schaltfläche, um die Sitzung auf derselben Seite fortzusetzen.

Deine Sitzung ist abgelaufen. Sie werden auf die Startseite weitergeleitet.