Make sure to sign up for an account today for exclusive coupons and free shipping on orders over $75!
Maximum quantity allowed is 999
Merci de sélectionner la quantité
Activin Receptor-like Kinase Inhibitor
No.186(Spring 2021)
1
SB431542 (1) is a specific and potent inhibitor of the activin receptor-like kinase (ALK) family, e.g., ALK4, ALK5, ALK7.1) 1 can also inhibit TGF-β-mediated activation of SMAD and induction of fibronectin and collagen expression in TGF-β-response cell lines.2)
Since Yamanaka et al. identified reprogramming factors for iPS (induced pluripotent stem) cells from somatic sells,3) chemical substitutes for these factors have also been developed.4,5) 1 can also replace Sox2, in reprogramming mouse fibroblasts to iPS cells.6)
The product is for research purposes only.
References
- 1) SB-431542 is a potent and specific inhibitor of transforming growth factor-β superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7
- 2) Inhibition of transforming growth factor (TGF)-β1–induced extracellular matrix with a novel inhibitor of the TGF-β type I receptor kinase activity: SB-431542
- 3) Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
- 4) Dissecting direct reprogramming through integrative genomic analysis
- 5) Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds
- 6) A small-molecule inhibitor of Tgf-β signaling replaces Sox2 in reprogramming by inducing Nanog
The prices are subject to change without notice. Please confirm the newest price by our online catalog before placing an order.
In addition, sales products changes with areas. Please understand that a product is not available when the product details page is not displayed.