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CAS RN: 89786-04-9 | Product Number: T3732
Tazobactam
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Purity: >97.0%(T)(HPLC)
Synonyms:
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 1G |
$71.00
|
Contact Us | 2 | 31 |
|
| 5G |
$212.00
|
Contact Us | Contact Us | 6 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | T3732 |
| Purity / Analysis Method | >97.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__0H__1__2N__4O__5S = 300.29 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 89786-04-9 |
| Reaxys Registry Number | 4787943 |
| PubChem Substance ID | 354335791 |
| Merck Index (14) | 9083 |
| MDL Number | MFCD00867002 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Purity(Neutralization titration) | min. 97.0 % |
| Specific rotation [a]20/D | +162 to +167 deg(C=1, DMF) |
Properties (reference)
| Melting Point | 172 °C(dec.) |
| Specific Rotation | 162° (C=1,DMF) |
| Solubility (soluble in) | Dimethylformamide |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H317 : May cause an allergic skin reaction. H334 : May cause allergy or asthma symptoms or breathing difficulties if inhaled. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. P285 : In case of inadequate ventilation wear respiratory protection. P280 : Wear protective gloves. P272 : Contaminated work clothing must not be allowed out of the workplace. P342 + P311 : If experiencing respiratory symptoms: Call a POISON CENTER/doctor. P304 + P341 : IF INHALED: If breathing is difficult, remove person to fresh air and keep comfortable for breathing. P302 + P352 : IF ON SKIN: Wash with plenty of soap and water. P333 + P313 : If skin irritation or rash occurs: Get medical advice/ attention. P363 : Wash contaminated clothing before reuse. |
Related Laws:
| RTECS# | XI0191400 |
Transport Information:
| HS Number | 2941.10.5000 |
Application
Tazobactam, A β-Lactamase Inhibitor for Antibiotics
Tazobactam and its sodium salt [T4106], β-lactamase inhibitors, are able to inhibit enzymes (β-lactamases) produced by bacteria that destroy β-lactam antibiotics like penicillins and cephalosporins. Therefore, it can increase antibacterial activity of antibiotics and also it can expend antibacterial spectrum and reduce adverse reaction, which has broad application prospect. Many combination agents with antibiotics have been developed against Pseudomonas aeruginosa or multidrug-resistant bacteria, such as MRSA. For your reference, related products (β-lactamase inhibitors for antibiotics) are sulbactam [S0868] and 3-aminophenylboronic acid [A1281].
References
- Kinetic interactions of tazobactam with β-lactamases from all major structural classes
- Piperacillin/Tazobactam: A review of its antibacterial activity, pharmacokinetic properties and therapeutic potential (a review)
- Ceftolozane/Tazobactam: A Novel Cephalosporin/β-Lactamase Inhibitor Combination with Activity Against Multidrug-Resistant Gram-Negative Bacilli (a review)
- New β-lactam-β-lactamase inhibitor combinations in clinical development (a review)4
- β-Lactamase Inhibitors: An Update
Application
Tazobactam, A β-Lactamase Inhibitor for Antibiotics
Tazobactam, a β-lactamase inhibitor, is able to inhibit enzymes (β-lactamases) produced by bacteria that destroy β-lactam antibiotics like penicillins and cephalosporins. Therefore, it can increase antibacterial activity of antibiotics and also it can expend antibacterial spectrum and reduce adverse reaction, which has broad application prospect. Many combination agents with antibiotics have been developed against Pseudomonas aeruginosa or multidrug-resistant bacteria, such as MRSA. For your reference, related products (β-lactamase inhibitors for antibiotics) are sulbactam [S0868] and 3-aminophenylboronic acid [A1281].
References
- Kinetic interactions of tazobactam with β-lactamases from all major structural classes
- Piperacillin/Tazobactam: A review of its antibacterial activity, pharmacokinetic properties and therapeutic potential (a review)
- Ceftolozane/Tazobactam: A Novel Cephalosporin/β-Lactamase Inhibitor Combination with Activity Against Multidrug-Resistant Gram-Negative Bacilli (a review)
- New β-lactam-β-lactamase inhibitor combinations in clinical development (a review)
- β-Lactamase Inhibitors: An Update
PubMed Literature
Articles/Brochures
TCIMAIL
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Specifications
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