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Published TCIMAIL newest issue No.197
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CAS RN: 53847-30-6 | Product Number: A3490
2-Arachidonoyl Glycerol (1% in Acetonitrile)
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Purity:
Synonyms:
- 2-AG (1% in Acetonitrile)
- 1,3-Dihydroxypropan-2-yl (5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenoate (1% in Acetonitrile)
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 1G |
424,00 €
|
1 | 27 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | A3490 |
| Molecular Formula / Molecular Weight | C__2__3H__3__8O__4 = 378.55 |
| Physical State (20 deg.C) | Liquid |
| Storage Temperature | Frozen (-80°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 53847-30-6 |
Specifications
| Appearance | Colorless to Almost colorlessclear liquid |
| Concentration(HNMR) | 1.0 to 1.4 % |
| NMR | confirm to structure |
Properties (reference)
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H311 : Toxic in contact with skin. H332 : Harmful if inhaled. H319 : Causes serious eye irritation. H370 : Causes damage to organs. H373 : May cause damage to organs through prolonged or repeated exposure. H225 : Highly flammable liquid and vapour. |
| Precautionary Statements | P260 : Do not breathe mist or vapours. P210 : Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. P233 : Keep container tightly closed. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P370 + P378 : In case of fire: Use dry sand, dry chemical or alcohol-resistant foam to extinguish. P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor. |
Related Laws:
| EC Number | 200-835-2 |
Transport Information:
| UN Number | UN1648 |
| Class | 3 |
| Packing Group | II |
| HS Number | 2918199890 |
Application
2-Arachidonylglycerol: An Endogenous Agonist of CB1 and CB2 Receptors
2-Arachidonylglycerol (2-AG) is an ester formed of arachidonic acid and glycerol, originally isolated from canine intestines.1) 2-AG an endocannabinoid that has been reported to act as an endogenous agonist of CB1 and CB2 receptors which are the primary molecular target responsible for the pharmacological effects of Δ9-tetrahydrocannabinol (THC), the psychoactive ingredient in Cannabis sativa. The endogenous cannabinoid system (ECS) is comprised of CB1 and CB2 receptors, and modulates neuronal and immune cell function, both of which play key roles in pain. Therefore, therapeutics targeting this system hold promise as novel analgesics.2-6) (The product is for research purpose only.)
References
- 1) Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors
- 2) An Introduction to the Endogenous Cannabinoid System (a review)
- 3) Regulation of inflammation by cannabinoids, the endocannabinoids 2-arachidonoyl-glycerol and arachidonoyl-ethanolamide, and their metabolites (a review)
- 4) Endocannabinoids and endocannabinoid-related mediators: Targets, metabolism and role in neurological disorders (a review)
- 5) 2-Arachidonoylglycerol: A signaling lipid with manifold actions in the brain (a review)
- 6) Recent advances in LC-MS/MS methods to determine endocannabinoids in biological samples: Application in neurodegenerative diseases (a review)
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