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| TCI Chemistry News October 2020 | ||||
| TCI offers an extensive catalog of 30,000 high quality organic reagents suitable for benchtop-to-bulk chemistry. This issue covers our chemistry expertise in 1,2-(bis)trifluoromethylation of arylalkynes using the copper complex, a powerful Lewis acid catalyst, the Corey-Fuchs reaction, and our latest issue of TCIMAIL 184. | ||||
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1,2-(Bis)trifluoromethylation of Arylalkynes Using the Copper ComplexA mild and efficient copper-mediated visible light promoted method towards 1,2-(bis)trifluoromethylated styrene derivatives to create E-hexafluorobutenes has been reported. The active trifluoromethylating agent (bpy)Cu(CF3)3 is bench stable and easily prepared from tetrabutylammonium tetrakis(trifluoromethyl)cuprate(III) [T3374] and 2,2'-bipyridyl [B0468]. While it has been known that (bpy)Cu(CF3)3 facilitates single trifluoromethylation it has been demonstrated that it can also add two trifluormethyl units. | ||||
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Powerful Lewis Acid CatalystN-(Trimethylsilyl)bis(trifluoromethanesulfonyl)imide [T2392] is an analogue of, TMSOTf and TMSN(SO2F)2, which has a very low electron density on its silicon atom and acts as a powerful Lewis acid catalyst in various reactions. For example, the Diels-Alder reaction using acrylates as dienophiles affords the corresponding addition products in high yields under mild conditions. | ||||
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Corey-Fuchs ReactionThe Corey-Fuchs reaction is a two-step reaction sequence used to convert aldehydes to terminal alkynes. The intermediate 1,1-dibromoalkene is produced from aldehydes, carbon tetrabromide [T0038] and triphenylphosphine [T0519] during the reaction sequence and can be isolated. This is then converted to the alkyne following the addition of a strong base such as butyllithium. | ||||
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TCI Chemistry Research: TCIMAIL 184Released in August, TCI's latest issue features Assoc. Prof. Makoto Ujike's article on infection called "Current Status of Drug development against the Novel Coronavirus, SARS-CoV-2”. We also feature research on:
Be sure to check out our previous issues of TCIMAIL that contain various scientific articles from researchers around the world! | ||||
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