Product Number	R0196
Molecular Formula / Molecular Weight	C₂₃H₂₄F₆N₅OPRu = 632.51
Physical State (20 deg.C)	Solid
Storage Temperature	Room Temperature (Recommended in a cool and dark place, <15°C)
Store Under Inert Gas	Store under inert gas
Condition to Avoid	Light Sensitive,Air Sensitive
Packaging and Container	1G-Glass Bottle with Plastic Insert (View image), 200MG-Glass Bottle with Plastic Insert (View image)
CAS RN	1259070-80-8
Reaxys Registry Number	21095236
PubChem Substance ID	354335346

Specifications

Appearance	Light yellow to Amber to Dark green powder to crystal
Elemental analysis(Nitrogen)	10.50 to 11.50 %
Specific rotation [a]20/D	+242 ～ +252 deg(C=0.1, CH3CN)
NMR	confirm to structure

Properties (reference)

GHS

Pictogram
Signal Word	Warning
Hazard Statements	H302 + H312 + H332 : Harmful if swallowed, in contact with skin or if inhaled. H315 : Causes skin irritation. H319 : Causes serious eye irritation.
Precautionary Statements	P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P271 : Use only outdoors or in a well-ventilated area. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water.Call a POISON CENTER/doctor if you feel unwell. P304 + P340 + P312 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell.

Related Laws:

Transport Information:

H.S.code*

2843.90-000

*This code is applied to the products when TCI exports from Japan and not for import in your country.

Application

Ru(II)-(S)-Pheox: Chiral Ru(II)-Catalyst for Enantioselective Cyclopropanation

Ru(II)-(S)-Pheox catalyst is a novel phenyloxazoline-Ru(II) complex, developed by Iwasa, et al. The catalyst shows highly enantioselective cyclopropanation of various oleﬁns using diazoacetates^1-6,8) or diazomethylphosphonates^7,8). The catalyst is a promising reagent for optically active cyclopropane derivatives which are present in a number of medicinally relevant compounds. In addition, the catalyst is also used for an enantioselective Si–H insertion reaction of α-diazo esters.⁹⁾ (Related products: (S)-Pheox [D5368])

References

1)Asymmetric Inter- and Intramolecular Cyclopropanation Reactions Catalyzed by a Reusable Macroporous-Polymer-Supported Chiral Ruthenium(II)/Phenyloxazoline Complex
- A.-M. Abu-Elfotoh, K. Phomkeona, K. Shibatomi, S. Iwasa, Angew. Chem., Int. Ed. 2010, 49, 8439.
2)Highly stereoselective Ru(II)–Pheox catalyzed asymmetric cyclopropanation of terminal olefins with succinimidyl diazoacetate
- S. Chanthamath, K. Phomkeona, K. Shibatomi, S. Iwasa, Chem. Commun. 2012, 48, 7750.
3)Highly Enantioselective Synthesis of Cyclopropylamine Derivatives via Ru(II)-Pheox-Catalyzed Direct Asymmetric Cyclopropanation of Vinylcarbamates
- S. Chanthamath, D. T. Nguyen, K. Shibatomi, S. Iwasa, Org. Lett. 2013, 15, 772.
4)Highly Stereoselective Cyclopropanation of α,β-Unsaturated Carbonyl Compounds with Methyl (Diazoacetoxy)acetate Catalyzed by a Chiral Ruthenium(II) Complex
- S. Chanthamath, D. S. Takaki, K. Shibatomi, S. Iwasa, Angew. Chem., Int. Ed. 2013, 52, 5818.
- Synfacts 2013, 9, 869.
5)Highly Regio- and Stereoselective Synthesis of Alkylidenecyclopropanes via Ru(II)-Pheox Catalyzed Asymmetric Inter- and Intramolecular Cyclopropanation of Allenes
- S. Chanthamath, H. W. Chua, S. Kimura, K. Shibatomi, S. Iwasa, Org. Lett. 2014, 16, 3408.
- Synfacts 2014, 10, 938.
6)Ru(II)–Pheox-Catalyzed Asymmetric Intramolecular Cyclopropanation of Electron-Deficient Olefins
- Y. Nakagawa, S. Chanthamath, K. Shibatomi, S. Iwasa, Org. Lett. 2015, 17, 2792.
- Synfacts 2015, 11, 847.
7)Highly Stereoselective Synthesis of Cyclopropylphosphonates Catalyzed by Chiral Ru(II)-Pheox Complex
- S. Chanthamath, S. Ozaki, K. Shibatomi, S. Iwasa, Org. Lett. 2014, 16, 3012.
8)Enantioselective Cyclopropanation of a Wide Variety of Olefins Catalyzed by Ru(II)–Pheox Complexes
- S. Chanthamath, S. Iwasa, Acc. Chem. Res. 2016, 46, 2080.
9)Ru(II)-Pheox-catalyzed Si–H insertion reaction: construction of enantioenriched carbon and silicon centers
- Y. Nakagawa, S. Chanthamath, I. Fujisawa, K. Shibatomia, S. Iwasa, Chem. Commun. 2017, 53, 3753.
- Synfacts 2017, 13, 0623.

PubMed Literature

Size	Unit Price	Same Day	2-3 Business Days	Other Lead Time	Shipping Information
200MG	A$157.00	27	0	Contact Us	Shipping Simulation
1G	A$498.00	≥40	0	Contact Us	Shipping Simulation

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CAS RN: 1259070-80-8 | Product Number: R0196

Ru(II)-(S)-Pheox Catalyst

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CAS RN: 1259070-80-8 | Product Number: R0196

Ru(II)-(S)-Pheox Catalyst

References

Articles/Brochures

Safety Data Sheet (SDS)

Specifications

C of A & Other Certificates

Sample C of A

Analytical Charts

Other Documents

Product Categories

Chemistry

Chemicals by Class

Chemistry

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