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CAS RN: 330786-25-9 | Product Number: P2687
PCI 29732
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Purity: >98.0%(HPLC)
Synonyms:
- 1-Cyclopentyl-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 10MG |
A$488.00
|
8 | 13 | Contact Us | |
| 50MG |
A$1,410.00
|
8 | 13 | Contact Us |
* Please contact our distributor of Chem-Supply
if you would like to purchase TCI products. The above prices do not include freight cost, customs charge and other charges to the destination.
* ChemSupply Australia Pty Ltd (Phone: 08-8440-2000 / email: sales@chemsupply.com.au)
* ChemSupply Australia Pty Ltd (Phone: 08-8440-2000 / email: sales@chemsupply.com.au)
| Product Number | P2687 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__2H__2__1N__5O = 371.44 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (<0°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 330786-25-9 |
| Reaxys Registry Number | 23187675 |
| MDL Number | MFCD25976874 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Elemental analysis(Nitrogen) | 18.00 to 19.50 % |
| Melting point | 141.0 to 145.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 143 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
Transport Information:
| H.S.code* | 2933.99-000 |
Application
PCI29732: A Highly Selective Irreversible Inhibitor for Bruton's Tyrosine Kinase (Btk)
PCI29732 is a selective irreversible inhibitor for Bruton's tyrosine kinase (Btk) which is a cytoplasmic tyrosine kinase important in B-lymphocyte development, differentiation, and signaling.1) In addition, the study recently has demonstrated that PCI29732 inhibits the function of ABCG2 by competitively binding to the ATP-binding site of ABCG2 and enhances the anti-tumor efficacy of substrate chemotherapeutic agents.2) (The product is for research purpose only.)
References
- 1) Discovery of selective irreversible inhibitors for Bruton's tyrosine kinase
- 2) PCI29732, a Bruton’s Tyrosine Kinase Inhibitor, Enhanced the Efficacy of Conventional Chemotherapeutic Agents in ABCG2-Overexpressing Cancer Cells
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