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CAS RN: 137-58-6 | Product Number: L0156
Lidocaine
Purity: >99.0%(T)(HPLC)
Synonyms:
- 2-Diethylamino-N-(2,6-dimethylphenyl)acetamide
Product Documents:
Size | Unit Price | Same Day | 2-3 Business Days |
---|---|---|---|
25G |
A$110.00
|
14 | ≥80 |
100G |
A$307.00
|
14 | 26 |
500G |
A$908.00
|
15 | ≥80 |
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* ChemSupply Australia Pty Ltd (Phone: 08-8440-2000 / email: sales@chemsupply.com.au)
Product Number | L0156 |
Purity / Analysis Method | >99.0%(T)(HPLC) |
Molecular Formula / Molecular Weight | C__1__4H__2__2N__2O = 234.34 |
Physical State (20 deg.C) | Solid |
Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
Store Under Inert Gas | Store under inert gas |
Condition to Avoid | Air Sensitive |
CAS RN | 137-58-6 |
Reaxys Registry Number | 2215784 |
PubChem Substance ID | 87572107 |
SDBS (AIST Spectral DB) | 27423 |
Merck Index (14) | 5482 |
MDL Number | MFCD00026733 |
Specifications
Appearance | White to Almost white powder to crystal |
Purity(HPLC) | min. 99.0 area% |
Purity(Nonaqueous Titration) | min. 99.0 % |
Melting point | 66.0 to 70.0 °C |
Solubility in Methanol | almost transparency |
Properties (reference)
Melting Point | 69 °C |
Boiling Point | 182 °C/4 mmHg |
Solubility in water | Insoluble |
Degree of solubility in water | 410 mg/l 30 °C |
Solubility (soluble in) | Alcohol, Benzene, Ether, Chloroform |
GHS
Pictogram | |
Signal Word | Danger |
Hazard Statements | H302 : Harmful if swallowed. H362 : May cause harm to breast-fed children. H370 : Causes damage to organs. H372 : Causes damage to organs through prolonged or repeated exposure. H317 : May cause an allergic skin reaction. |
Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P263 : Avoid contact during pregnancy/ while nursing. P272 : Contaminated work clothing should not be allowed out of the workplace. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves. P302 + P352 : IF ON SKIN: Wash with plenty of water. P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor. P362 + P364 : Take off contaminated clothing and wash it before reuse. P333 + P313 : If skin irritation or rash occurs: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P405 : Store locked up. |
Related Laws:
RTECS# | AN7525000 |
Transport Information:
H.S.code* | 2924.29-000 |
Application
Lidocaine: A Voltage Gated Sodium Channel Blocker
Lidocaine is widely used for regional anesthesia and postoperative pain relief, and these effects involve the blockade of voltage-dependent sodium channels which play a key role in the pathogenesis of neuropathic pain. Thus, lidocaine stabilizes the neuronal cell membrane by inhibiting the movement of sodium ions into a nerve cell. Lignocaine is also a class IB antiarrhythmic agent as a sodium channel blocker. Lidocaine is metabolized rapidly by CYP1A2 and CYP3A4 in liver to main active metabolites, monoethylglycine xylidide (MEGX) [N1171] and glycinexylidide (GX) [G0579]. (The product is for research purpose only.)
References
- Lidocaine block of cardiac sodium channels
- Molecular determinants of state-dependent block of Na+ channels by local anesthetics
- The role of sodium channels in chronic inflammatory and neuropathic pain (a review)
- High-performance liquid chromatography-tandem electrospray mass spectrometry for the determination of lidocaine and its metabolites in human plasma and urine
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