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Published TCIMAIL newest issue No.197
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Glycogen Synthase Kinase 3 (GSK3) Inhibitor: SB 216763
No.179(November 2018)
SB 216763 (1) is a potent and selective cell permeable glycogen synthase kinase 3 (GSK3) inhibitor.1) The inhibitory mechanism is ATP-competitive. The Ki and IC50 of 1 to GSK-3α are 9.10 nM and 34.3 nM, respectively.
1 can maintain mESCs in a pluripotent state in the absence of exogenous leukemia inhibitory factor (LIF) when cultured on mouse embryonic fibrobrasts (MEFs).2) 1 promotes the generation of hematopoietic stem cells (HSCs) in aorta-gonad-mesonephros (AGM) explants.3)This product is for research purpose only.
1 can maintain mESCs in a pluripotent state in the absence of exogenous leukemia inhibitory factor (LIF) when cultured on mouse embryonic fibrobrasts (MEFs).2) 1 promotes the generation of hematopoietic stem cells (HSCs) in aorta-gonad-mesonephros (AGM) explants.3)
References
- 1)Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription
- 2)Glycogen synthase kinase 3 (GSK3) inhibitor, SB-216763, promotes pluripotency in mouse embryonic stem cells
- 3)Hematopoietic stem cell development requires transient Wnt/β-catenin activity
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