Published TCIMAIL newest issue No.197
Maximum quantity allowed is 999
Bitte wählen Sie die Menge aus.
Tyrosine Kinase Inhibitor: Methyl 2,5-Dihydroxycinnamate
No.173(April 2017)
Erbstatin, an inhibitor of epidermal growth factor receptor (EGFR)-associated tyrosine kinase, was isolated from Actinomycetes.1) Methyl 2,5-dihydroxycinnamate (1) is an analog of erbstatin and inhibits EGFR-associated tyrosine kinase in vitro.2) 1 has also been shown to inhibit autophosphorylation of EGFR.2) As shown in the Table, 1 inhibits EGF-induced phenotype change in EGFR-overexpressing NIH3T3 (ER12) cells.3) 1 is demonstrated to be about 4 times more stable than erbstatin in calf serum.2)
References
- 1)Studies on a new epidermal growth factor-receptor kinase inhibitor, erbstatin, produced by MH435-hF3
- 2)Inhibition of epidermal growth factor-induced DNA synthesis by tyrosine kinase inhibitors
- 3)Inhibition of epidermal growth factor receptor functions by tyrosine kinase inhibitors in NIH3T3 cells
The prices are subject to change without notice. Please confirm the newest price by our online catalog before placing an order.
In addition, sales products changes with areas. Please understand that a product is not available when the product details page is not displayed.
In addition, sales products changes with areas. Please understand that a product is not available when the product details page is not displayed.