TCI Chemistry News
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May 2023
TCI offers an extensive catalog of over 30,000 high quality organic reagents suitable for benchtop-to-bulk chemistry. This issue covers our chemistry topics as follows:
- Cubane-Containing Building Blocks: the Bioisostere of Benzene Ring
- Mediator for Organic Electrochemical Reactions
- The Deoxyfluorination of Alcohol Using a Photoredox Catalyst
- Chemoselective Reduction of Nitro Group Using Diboronic Acid

Cubane-Containing Building Blocks: the Bioisostere of Benzene Ring
In the field of drug design, cubane is considered to be the bioisostere of benzene due to its diagonal distance of the skeleton being almost the same as the diameter of benzene. The strategy to introduce the cubane skeleton instead of the benzene ring has gathered much interest in recent drug discovery. This is expected to improve solubility and pharmacokinetics by breaking the planarity of the entire molecule. TCI offers a series of cubane compounds with various functional groups (D5542, M3466, M3505, C3810, C3808, B6415) useful for derivatization, and also can provide custom synthesis of various derivatives related to these compounds.
Mediator for Organic Electrochemical Reactions
Recently, organic electrochemical reactions have attracted much attention due to their high functional group tolerance and high energy efficiency, and have been applied to the total synthesis of natural products. TCNHPI [H1765] is utilized as a mediator in organic electrochemical reactions. So far, the scalable allylic C-H bond oxidation of terpenes such as valencene and steroids using H1765 as a mediator have been reported.
TCI Practical Example: The Deoxyfluorination of Alcohol Using a Photoredox Catalyst
We are proud to present the deoxyfluorination of 2-methyl-4-phenyl-2-butanol with F-TEDA-BF4 in the presence of [Ir(p-F(Me)ppy)2-(4,4'-dtbbpy)]PF6 [B6258], a photoredox iridium catalyst. The tertiary alcohol activated as an oxalate half-ester is utilized as an efficient radical precursor to conduct C-F coupling.
TCI Practical Example: Chemoselective Reduction of Nitro Group Using Diboronic Acid
TCI introduces the selective reduction of nitro groups from trans-4-nitrostilbene to trans-4-aminostilbene using diboronic acid [T2953] and 4,4'-bipyridyl.Upcoming Events
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