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| TCI Life Science News August 2020 | ||||
| At TCI, we support discovery in life sciences through our knowledge and expertise in organic small molecules. In this issue we focus on our new CUBIC reagents, fluorescence probes for detection, calcium chelators and PDE4 inhibitors. We also have thousands of other useful compounds available only at TCI for your research and development. | ||||
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New CUBIC Reagents: X1/X2 and Mounting SolutionTissue-Clearing Reagent CUBIC-X1 [T3866] and Tissue-Clearing Reagent CUBIC-X2 [T3867] can clear animal tissues with expansion. TCI also offers Mounting Solution (RI 1.520) [M3294] and Mounting Solution (RI 1.467) [M3292] for soaking cleared tissue samples during observation. M3294 is suitable for cleared tissue samples using CUBIC-R+, and M3292 is suitable for cleared tissue samples using CUBIC-X2, respectively. | ||||
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Fluorescence Probes for DetectionFluorescence imaging is an important research method in the field of life science. TCI offers many fluorescence probes which can be used for various experiments such as fluorescence staining, flow cytometry, florescent western blotting, and FLISA. You can see application data and some fluorescence micrographs. | ||||
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Highly Selective Rapid Calcium ChelatorsBAPTA [B3895] and BAPTA-Na4 [T2844] are highly selective chelators for Ca2+ over Mg2+. Their selectivity for Ca2+ is higher than the selectivity of EGTA, and the binding does not depend on pH. Their chelation reactions are more rapid than that of EGTA, thus, it has been reported that the distances between Ca2+ channels and Ca2+ sensors in neurons can be evaluated by analyzing the transmitter release inhibition by different chelators. While both BAPTA and BAPTA-Na4 are membrane-impermeable, BAPTA-AM [T2845], a BAPTA ester, is membrane-permeable and can chelate with Ca2+ in cells after the hydrolysis by intracellular esterases. | ||||
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PDE4 Inhibitor and its EnantiomersRolipram [R0110] is a selective inhibitor of phosphodiesterases 4 (PDE4s). PDE4s are responsible for hydrolysis of the cyclic nucleotides cAMP and cGMP to 5'-AMP and 5'-GMP, respectively, particularly in nerve and immune cells. The inhibition of PDE4s by rolipram induces the elevation of intracellular cAMP concentration. Consequences rolipram-induced elevation of cAMP suppress expression of proinflammatory cytokines and other mediators of inflammation. (R)-(−)-Rolipram [R0182] is the active enantiomer of rolipram, and has been reported that (R)-(−)-rolipram is approximately 3 times more potent than (S)-(+)-rolipram [R0183] against PDE4s. | ||||
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