Published TCIMAIL newest issue No.197
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An Antibiotic Substance in Cordyceps sinensis
Cordyceps is a genus of fungi which are parasitic in insects. Cordyceps sinensis germinating in larvae of ghost moths, and Cordyceps militaris parasitizing lepidopterous larvae have been used for traditional Chinese medicine. Cordycepin (cordycepin hydrate) (1), one of the bioactive components in Cordyceps, has a chemical structure similar to that of adenosine. Therefore, 1 shows antitumor effects because of its inhibitory activity against RNA polyadenylation, etc.3-6) Furthermore, an insecticidal effect7) and an antibacterial effect8) of 1 have been reported also.
References
- 1)Pharmacological actions of Cordyceps, a prized folk medicine
- 2)Cordyceps fungi: natural products, pharmacological functions and developmental products
- 3)Antitumour activity of cordycepin in mice
- 4)Antitumor effect of cordycepin (3'-deoxyadenosine) on mouse melanoma and lung carcinoma cells involves adenosine A3 receptor stimulation
- 5)The apoptotic effect of cordycepin on human OEC-M1 oral cancer cell line
- 6)RNA-directed agent, cordycepin, induces cell death in multiple myeloma cells
- 7)Larvicidal activity against Plutella xylostella of cordycepin from the fruiting body of Cordyceps militaris
- 8)Cordycepin: selective growth inhibitor derived from liquid culture of Cordyceps militaris against Clostridium spp.
