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CAS RN: 1450-14-2 | Product Number: H0638
Hexamethyldisilane
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Purity: >98.0%(GC)
Synonyms:
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 10ML |
$35.00
|
2 | Contact Us | ≥100 |
|
| 100ML |
$199.00
|
4 | Contact Us | ≥40 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | H0638 |
| Purity / Analysis Method | >98.0%(GC) |
| Molecular Formula / Molecular Weight | C__6H__1__8Si__2 = 146.38 |
| Physical State (20 deg.C) | Liquid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Moisture Sensitive |
| CAS RN | 1450-14-2 |
| Reaxys Registry Number | 1633463 |
| PubChem Substance ID | 87571012 |
| SDBS (AIST Spectral DB) | 18249 |
| MDL Number | MFCD00008258 |
Specifications
| Appearance | White or Colorless to Light yellow powder to lump to clear liquid |
| Purity(GC) | min. 98.0 % |
Properties (reference)
| Melting Point | 13 °C |
| Boiling Point | 113 °C |
| Flash point | -9 °C |
| Specific Gravity (20/20) | 0.73 |
| Refractive Index | 1.42 |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H319 : Causes serious eye irritation. H317 : May cause an allergic skin reaction. H335 : May cause respiratory irritation. H413 : May cause long lasting harmful effects to aquatic life. H225 : Highly flammable liquid and vapor. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. P273 : Avoid release to the environment. P240 : Ground/bond container and receiving equipment. P210 : Keep away from heat/sparks/open flames/hot surfaces. No smoking. P233 : Keep container tightly closed. P243 : Take precautionary measures against static discharge. P241 : Use explosion-proof electrical/ ventilating/ lighting/ equipment. P242 : Use only non-sparking tools. P271 : Use only outdoors or in a well-ventilated area. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P272 : Contaminated work clothing must not be allowed out of the workplace. P370 + P378 : In case of fire: Use dry sand, dry chemical or alcohol-resistant foam to extinguish. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P303 + P361 + P353 : IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower. P333 + P313 : If skin irritation or rash occurs: Get medical advice/ attention. P363 : Wash contaminated clothing before reuse. P304 + P340 + P312 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell. P403 + P233 : Store in a well-ventilated place. Keep container tightly closed. P403 + P235 : Store in a well-ventilated place. Keep cool. P405 : Store locked up. |
Related Laws:
| RTECS# | JM9170000 |
Transport Information:
| UN Number (DOT-AIR) | UN1993 |
| Class (DOT-AIR) | 3 |
| Packing Group (TCI-A) | II |
| HS Number | 2931.90.9010 |
Application
A Novel Cyanation Reaction of Arenes Using Acetonitrile as a Cyano Source
[Experimental Procedure]
Cyanation of Cumene (R=i-Pr) : An oven-dried Schlenk tube equipped with a magnetic stir bar is evacuated and backfilled with O2 three times. Cumene (0.5 mmol), N-iodosuccinimide (NIS) (1.05 eq., 0.525 mmol), Cu(ClO4)2·6H2O (20 mol%, 0.1 mmol), acetonitrile (1.2 mL) are added into the tube and the reaction is stirred at 150°C for 1 hour. The reaction mixture is allowed to cool down. Under O2, 1,10-phenanthroline (20 mol%, 0.1 mmol), TEMPO free radical (2 eq., 1 mmol), hexamethyldisilane (1 eq., 0.5 mmol) are added into the reaction mixture. The reaction is then heated up to 150°C for 2.5 days under O2. After completion, the insoluble is removed by filtration. The filtrate is concentrated under vacuo and the residue is purified by column chromatography on silica gel using EtOAc / petroleum ether to give the corresponding p- or o-cyanated cumenes as a yellow liquid (65 mg, 90% yield, p:o = 6:1).
Cyanation of Cumene (R=i-Pr) : An oven-dried Schlenk tube equipped with a magnetic stir bar is evacuated and backfilled with O2 three times. Cumene (0.5 mmol), N-iodosuccinimide (NIS) (1.05 eq., 0.525 mmol), Cu(ClO4)2·6H2O (20 mol%, 0.1 mmol), acetonitrile (1.2 mL) are added into the tube and the reaction is stirred at 150°C for 1 hour. The reaction mixture is allowed to cool down. Under O2, 1,10-phenanthroline (20 mol%, 0.1 mmol), TEMPO free radical (2 eq., 1 mmol), hexamethyldisilane (1 eq., 0.5 mmol) are added into the reaction mixture. The reaction is then heated up to 150°C for 2.5 days under O2. After completion, the insoluble is removed by filtration. The filtrate is concentrated under vacuo and the residue is purified by column chromatography on silica gel using EtOAc / petroleum ether to give the corresponding p- or o-cyanated cumenes as a yellow liquid (65 mg, 90% yield, p:o = 6:1).
References
- Acetonitrile as a Cyanating Reagent: Cu-Catalyzed Cyanation of Arenes
Application
Stereospecific deoxygenation
References
- P. B. Dervan, M. A. Shippey, J. Am. Chem. Soc. 1976, 98, 1265.
- H. Vorbruggem, K. Krolikiewicz, Tetrahedron Lett. 1984, 25, 1259.
- H. Matsumoto, S. Koike, I. Matsubara, T. Nakano, Y. Nagai, Chem. Lett. 1982, 533.
- H. Sakurai, F. Kondo, J. Organomet. Chem. 1975, 92, C46.
- W. C. Still, J. Org. Chem. 1976, 41, 3063.
PubMed Literature
Articles/Brochures
TCIMAIL
[Research Articles] A Novel Cyanation Reaction of Arenes Using Acetonitrile as a Cyano SourceProduct Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Specifications
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