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CAS RN: 66575-29-9 | Product Number: F0855
Forskolin
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Purity: >95.0%(HPLC)
Synonyms:
- Coleonol
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 10MG |
$144.00
|
2 | 1 | ≥100 |
|
| 50MG |
$486.00
|
1 | 1 | ≥100 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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| Product Number | F0855 |
| Purity / Analysis Method | >95.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__2H__3__4O__7 = 410.51 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container | 10MG-Glass Bottle with Plastic Insert (View image), 50MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 66575-29-9 |
| Reaxys Registry Number | 4300863 |
| PubChem Substance ID | 253661985 |
| Merck Index (14) | 2476 |
| MDL Number | MFCD00082317 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Melting point | 226.0 to 230.0 °C |
Properties (reference)
| Melting Point | 228 °C |
| Specific Rotation | -17° |
| Maximum Absorption Wavelength | 305 nm |
GHS
Related Laws:
| RTECS# | QL6150000 |
Transport Information:
| HS Number | 2932.99.9090 |
Application
Research on regenerative medicine
Forskolin was utilized for establishing chemically induced pluripotent stem cells (iPSCs) as one of the chemical “substitutes” of Oct4, which is one of four transcription factors (Oct4, Klf4, Sox2, and c-Myc or Oct4, Sox2, Nanog, and Lin28).1) It also induces differentiation of mesenchymal stem cells into neuron-like cells.2)
References
- 1) Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds
- 2) cAMP induces neuronal differentiation of mesenchymal stem cells via activation of extracellular signal-regulated kinase/MAPK
Application
Forskolin: A Diterpene Activator of Cyclic AMP-Generating Systems
Forskolin (also called Coleonol) is a diterpene that is produced by the Indian Coleus plant (Coleus forskohlii). Forskolin directly activates adenylyl cyclase (AC) and raises 3',5'-cyclic AMP (cAMP) levels in a wide variety of cell types. AC catalyzes the conversion of ATP to cAMP and pyrophosphate. cAMP is an important second messenger important in many biological processes.
References
- Forskolin: Unique diterpene activator of adenylate cyclase in membranes and in intact cells
- Forskolin: its biological and chemical properties (a review)
- K. B. Seamon, J. W. Daly, Adv. Cyclic Nucleotide Protein Phosphorylation Res. 1986, 20, 1.
- Forskolin: a specific stimulator of adenylyl cyclase or a diterpene with multiple sites of action? (a rview)
- Apoptosis in cerebellar granule cells is blocked by high KCl, forskolin, and IGF-1 through distinct mechanisms of action: the involvement of intracellular calcium and RNA synthesis
- Forskolin as a tool for examining adenylyl cyclase expression, regulation, and G protein signaling (a review)
PubMed Literature
Articles/Brochures
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Specifications
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