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CAS RN: 208255-80-5 | Product Number: D4257
DAPT
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Purity: >97.0%(HPLC)
Synonyms:
- (3,5-Difluorophenylacetyl)-Ala-Phg-OtBu
- (3,5-Difluorophenylacetyl)-L-alanyl-L-2-phenylglycine tert-Butyl Ester
- tert-Butyl (S)-2-[(S)-2-[2-(3,5-Difluorophenyl)acetamido]propanamido]-2-phenylacetate
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 25MG |
$440.00
|
Contact Us | 1 | 20 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | D4257 |
| Purity / Analysis Method | >97.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__3H__2__6F__2N__2O__4 = 432.47 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 208255-80-5 |
| Reaxys Registry Number | 9588440 |
| PubChem Substance ID | 253659655 |
| MDL Number | MFCD04974585 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Elemental analysis(Nitrogen) | 6.20 to 6.70 % |
| NMR | confirm to structure |
Properties (reference)
GHS
Related Laws:
Transport Information:
| HS Number | 2924.29.7790 |
Application
γ-Secretase Inhibitor
References
- 1)Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain
- 2)The Notch signaling inhibitor DAPT down-regulates cdk5 activity and modulates the distribution of neuronal cytoskeletal proteins
- 3)Notch signaling: A simple pathway becomes complex
- 4)The Notch response inhibitor DAPT enhances neuronal differentiation in embryonic stem cell-derived embryoid bodies independently of sonic hedgehog signaling
PubMed Literature
Articles/Brochures
TCIMAIL
[TCIMAIL No.162] γ-Secretase Inhibitor[Featured Products] Regenerative Medicine Related Reagents
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Specifications
C of A & Other Certificates
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Other Documents
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DAPT [Optimized for Cell Culture]
| Product # | D6295 |
| CAS RN | 208255-80-5 |
| Purity / Analysis Method: |