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Published TCIMAIL newest issue No.197
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CAS RN: 50924-49-7 | Product Number: M2399
Mizoribine
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Purity: >98.0%(HPLC)
Synonyms:
- 1-(β-D-Ribofuranosyl)-5-hydroxyimidazole-4-carboxamide
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 50MG |
60,00 €
|
1 | 11 |
|
| 250MG |
207,00 €
|
1 | 8 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
Supplemental Product Information:
This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
| Product Number | M2399 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__9H__1__3N__3O__6 = 259.22 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 50924-49-7 |
| Reaxys Registry Number | 8155135 |
| PubChem Substance ID | 253659680 |
| Merck Index (14) | 6222 |
| MDL Number | MFCD00057221 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Specific rotation [a]20/D | -25.0 to -27.0 deg(C=2,H2O) |
Properties (reference)
| Melting Point | 198 °C(dec.) |
| Specific Rotation | -26° (C=2,H2O) |
| Maximum Absorption Wavelength | 280 nm |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. H360 : May damage fertility or the unborn child. H340 : May cause genetic defects. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P337 + P313 : If eye irritation persists: Get medical advice/ attention. |
Related Laws:
| RTECS# | NI3980000 |
Transport Information:
| HS Number | 2940000080 |
Application
Mizoribine: An Imidazole Nucleoside Immunosuppressive and Antiviral Agent
Mizoribine (bredinin, MZR), an imidazole nucleoside, is an immunosuppressive and an antiviral agent. The immunosuppressive effect of mizoribine has been reported to be due to the inhibition of de novo guanosine synthesis, via inhibition of inosine-5'-monophosphate dehydrogenase (IMPDH).1-4) On the other hand, the combination of mizoribine and interferon (IFN)-α have been reported to show antiviral activities. The mechanisms of action would appear that mizoribine inhibits virus RNA replication based on the depletion of the intracellular pool of guanosine nucleotides by IMPDH inhibition.5-7) In addition, mizoribine has been reported to its anti-coronavirus activity.８) (The product is for research purpose only.)
References
- 1)Studies on bredinin. I. Isolation, characterization, and biological properties
- 2)Guanine ribonucleotide depletion inhibits T cell activation. Mechanism of action of the immunosuppressive drug mizoribine
- 3)Comparison of the effects of mizoribine with those of azathioprine, 6-mercaptopurine, and mycophenolic acid on T lymphocyte proliferation and purine ribonucleotide metabolism
- 4)Mizoribine and mycophenolate mofetil (a review)
- 5)Antiviral activities of mizoribine and other inosine monophosphate dehydrogenase inhibitors against several ortho-and paramyxoviruses
- 6)Mizoribine inhibits hepatitis C virus RNA replication: Effect of combination with interferon-α
- 7)Inhibition of bovine viral diarrhea virus (BVDV) by mizoribine: synergistic effect of combination with interferon-α
- 8)Inhibitory effect of mizoribine and ribavirin on the replication of severe acute respiratory syndrome (SARS)-associated coronavirus
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